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Effects of hydroxy groups in the A-ring on the anti-proteasome activity of flavone
http://hdl.handle.net/10271/3143
http://hdl.handle.net/10271/3143501820b7-400b-4f40-8ca9-2431525045dd
名前 / ファイル | ライセンス | アクション |
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論文本文 (762.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2017-01-28 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of hydroxy groups in the A-ring on the anti-proteasome activity of flavone | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ubiquitin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | flavonoid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | proteasome | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | inhibitor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他のタイトル | ||||||
その他のタイトル | フラボンの抗プロテアソーム活性におけるA環のヒドロキシル基の効果 | |||||
言語 | ja | |||||
著者 |
Nakamura, Kasumi
× Nakamura, Kasumi |
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書誌情報 |
en : Biological and Pharmaceutical Bulletin 巻 38, 号 6, p. 935-940, 発行日 2015-06-01 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 日本薬学会 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | The Pharmaceutical Society of Japan | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ubiquitin-proteasome pathway plays an important role in regulating apoptosis and the cell cycle. Recently, proteasome inhibitors have been shown to have antitumor effects and have been used in anticancer therapy for several cancers such as multiple myeloma. Although some flavones, such as apigenin, chrysin and luteolin, have a specific role in the inhibition of proteasome activity and induced apoptosis in some reports, these findings did not address all flavone types. To further investigate the proteasome-inhibitory mechanism of flavonoids, we examined the inhibitory activity of 5,6,7-trihydroxyflavone, baicalein and 5,6,7,4′-tetrahydroxyflavone, scutellarein on extracted proteasomes from mice and cancer cells. Unlike the other flavones, baicalein and scutellarein did not inhibit proteasome activity or accumulate levels of ubiquitinated proteins. These results indicate that flavones with hydroxy groups at positions 5, 6 and 7 of the A-ring lack the anti-proteasome function. | |||||
言語 | en | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位の区分 | ||||||
内容記述タイプ | Other | |||||
内容記述 | doctoral | |||||
言語 | en | |||||
学位の分野 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 医学系研究科 | |||||
言語 | ja | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13802 | |||||
言語 | ja | |||||
学位授与機関名 | 浜松医科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-03-14 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲第721号 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0918-6158 | |||||
EISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1347-5215 | |||||
NII論文ID | ||||||
識別子タイプ | NAID | |||||
関連識別子 | 130005118804 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 25810454 | |||||
出版社DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1248/bpb.b15-00018 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |