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Ultrastructural localization of cochlin in the rat cochlear duct
http://hdl.handle.net/10271/2045
http://hdl.handle.net/10271/2045fbf913eb-00e7-4d32-aa73-67a3448de738
名前 / ファイル | ライセンス | アクション |
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論文本文 (2.6 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2013-08-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Ultrastructural localization of cochlin in the rat cochlear duct | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hereditary hearing impairment | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DFNA9 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | COCH | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Inner ear | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Immunogold method | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他のタイトル | ||||||
その他のタイトル | ラット蝸牛管におけるコクリンの超微細構造的な局在 | |||||
言語 | ja | |||||
著者 |
Hosokawa, Seiji
× Hosokawa, Seiji |
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書誌情報 |
en : Audiology & neuro-otology 巻 15, 号 4, p. 247-253, 発行日 2009-11-10 |
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出版者 | ||||||
言語 | en | |||||
出版者 | S. Karger AG | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright 2009 S. Karger AG, Basel | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cochlin, a product of the COCH gene, is a major constituent of the inner ear extracellular matrix. Type II collagen, a protein that contributes to structural stability, is similarly a component of this extracellular matrix. In this study, using the postembedding immunogold method, we demonstrate the localization of cochlin and type II collagen in the cochlear duct at the ultrastructural level. The immunolabeling of cochlin was observed in the fibrillar substance in the spiral limbus, beneath the inner sulcus cells, and in the basilar membrane, the spiral prominence and the spiral ligament. Immunolabeling of type II collagen was observed in the same fibrillar substance in the extracellular matrix of the cochlear duct. This localization of cochlin is consistent with the expected localization of type II collagen. The localization of cochlin and type II collagen indicates the important roles played by these proteins in the hearing process. | |||||
言語 | en | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 浜松医科大学学位論文 医博論第474号(平成21年12月11日) | |||||
言語 | ja | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位の区分 | ||||||
内容記述タイプ | Other | |||||
内容記述 | doctoral | |||||
言語 | en | |||||
学位の分野 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 医学系研究科 | |||||
言語 | ja | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13802 | |||||
言語 | ja | |||||
学位授与機関名 | 浜松医科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2009-12-11 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙第474号 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 1420-3030 | |||||
EISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1421-9700 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 19907161 | |||||
出版社DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1159/000256664 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |