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Expression and functional role of β-adrenoceptors in the human urinary bladder urothelium
http://hdl.handle.net/10271/833
http://hdl.handle.net/10271/833b99904bb-983e-4fa7-bc61-37f71daf0b21
名前 / ファイル | ライセンス | アクション |
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論文本文 (501.4 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2013-08-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression and functional role of β-adrenoceptors in the human urinary bladder urothelium | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | human urothelium | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | β-adrenoceptor agonist | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mucosa | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | β3-adrenoceptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bladder | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | nitric oxide | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
その他のタイトル | ||||||
その他のタイトル | ヒト膀胱上皮におけるβ-アドレナリン受容体の発現と機能的役割 | |||||
言語 | ja | |||||
著者 |
Otsuka, Atsushi
× Otsuka, Atsushi |
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書誌情報 |
en : Naunyn-Schmiedeberg's Archives of Pharmacology 巻 377, 号 4-6, p. 473-481, 発行日 2008-06 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright Springer-Verlag 2008 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the presence of β-adrenoceptor subtypes in human urinary bladder urothelium and examined whether β-adrenoceptors in the urothelium modulate the relaxation responses of isolated human detrusor strips to a β-adrenoceptor agonist. Expression of β1-, β2- and β3-adrenoceptor mRNA in urothelium and detrusor smooth muscle was determined by reverse transcription-polymerase chain reaction (RT-PCR), and the distribution of β1-, β2- and β3-adrenoceptors in human urinary bladder urothelium was examined by immunohistochemistry. Paired human longitudinal detrusor strips with and without an intact urothelium were suspended in organ baths to construct concentration-response curves to isoproterenol. The possible involvement of urothelium-derived nitric oxide (NO) in this response was examined in additional experiments with urothelium-intact strips in the presence of NG-nitro-L-arginine methylester (L-NAME). Results confirmed the expression of β1-, β2- and β3-adrenoceptors in the human urinary bladder urothelium. Further, the presence of the urothelium caused a parallel rightward shift of the concentration-response curve to isoproterenol, with a significant reduction in potency (pEC50). L-NAME failed to exert any significant effect on the relaxation response to isoproterenol in the urothelium-intact strips. These results confirm the presence of β1-, β2- and β3-adrenoceptors in human urinary bladder urothelium. Further, they suggest that urothelial β-adrenoceptors induce the release of a urothelium-derived factor which inhibits the β-adrenoceptor agonist-induced relaxation of the human detrusor smooth muscle, and that this inhibitory mechanism might not involve NO. | |||||
言語 | en | |||||
注記 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 浜松医科大学学位論文 医博論第456号(平成20年7月18日) | |||||
言語 | ja | |||||
学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位の区分 | ||||||
内容記述タイプ | Other | |||||
内容記述 | doctoral | |||||
言語 | en | |||||
学位の分野 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 医学系研究科 | |||||
言語 | ja | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13802 | |||||
言語 | ja | |||||
学位授与機関名 | 浜松医科大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2008-07-18 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙第456号 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0028-1298 | |||||
EISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 1432-1912 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 18311486 | |||||
出版社DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00210-008-0274-y | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa |