Fourteen phenothiazine derivatives were tested for their detection by gas chromatography (GC) -surface ionization detection(SID). The sensitivity of GC-SID was highest with trimeprazine and levomepromazine and lowest with thiethylperazine and thioproperazine containing sulfur residues in their structurs. The detection limit of chlorpromazine was as low as 10 pg in an injected volume. A detailed procedure for isolation of phenothiazines from human whole blood by the use of Sep-Pak C18 cartridges. before the GC-SID.is also presented.
表面電離検出ガスクロマトグラフィーによる血中フェノチアジン系薬物の高感度検出
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