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Congenital Infection and Disorders of Brain Development : With Special Reference to Congenital Cytomegalovirus Infection 【Review】 TSUTSUI, Yoshihiro 筒井, 祥博 KOSUGI, Isao 小杉, 伊三夫 SHINMURA, Yuichiro 新村, 祐一郎 NAGAHAMA, Masato 長浜, 真人 open access (C) 日本先天異常学会 本文データは学協会の許諾に基づきCiNiiから複製したものである congenital infection cytomegalovirus brain development Intrauterine infections of various microorganisms have the potential to induce brain abnormalities in the fetus and newborn infant. Among the infectious pathogens, cytomegalovirus (CMV) is the most significant infectious cause of brain abnormalities, with variations from fatal cytomegalic inclusion disease to functional brain disorders, such as mental retardation or epilepsy. Here, we present three autopsy cases of congenital CMV infection, and we review the features of the brain abnormalities of congenital CMV infection. A ventriculofugal spread of infection seems to be characteristics of congenital CMV-infected brains and is suggested to be the cause of neuronal migration disorders, resulting in brain malformations, such as microcephaly, lissencephaly and polymicrogyria. We also present an experimental animal model for congenital CMV infection. With the model we showed that murine cytomegalovirus (MCMV) infection in the developing mouse brain caused a disturbance of neuronal migration and neuronal cell loss, detected with morphometric measurements by labeling the neuronal precursor cells with BrdU. As shown by immunohistochemical double staining of BrdU and viral-antigen, infected neuronal cells constituted only a part of the disordered neuronal cells, suggesting that an indirect effect of vital infection on neuronal cells also contributes the migration disorders presumably mediated by cytokines or the induction of apoptosis. Neuronal migration disorders caused by MCMV infection are also discussed with reference to those caused by X-irradiation. 日本先天異常学会 John Wiley and Sons 1997-03-31 eng journal article VoR http://hdl.handle.net/10271/421 https://hama-med.repo.nii.ac.jp/records/393 110002787970 https://doi.org/10.1111/j.1741-4520.1997.tb00543.x 0914-3505 1741-4520 AN10066760 Congenital anomalies 37 1 1 14 https://hama-med.repo.nii.ac.jp/record/393/files/110002787970.pdf application/pdf 1.8 MB 2018-08-27