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Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury. 末梢神経損傷後のアラキドン酸含有ホスファチジルコリンの増加は脊髄内の活性化ミクログリアとアストロサイトに関連している 徐, 冬閩 open access doctoral 医学系研究科 Peripheral nerve injury (PNI) triggers cellular and molecular changes in the spinal cord. However, little is known about how the polyunsaturated fatty acid-containing phosphatidylcholines (PUFA-PCs) are regulated in the spinal cord after PNI and the association of PUFA-PCs with the non-neuronal cells within in the central nervous system (CNS). In this study, we found that arachidonic acid-containing phosphatidylcholine (AA-PC), [PC(16:0/20:4)+K]+, was significantly increased in the ipsilateral ventral and dorsal horns of the spinal cord after sciatic nerve transection, and the increased expression of [PC(16:0/20:4)+K]+ spatiotemporally resembled the increase of reactive microglia and the astrocytes. From the lipidomics point of view, we conclude that [PC(16:0/20:4)+K]+ could be the main phospholipid in the spinal cord influenced by PNI, and the regulation of specific phospholipid molecule in the CNS after PNI is associated with the reactive microglia and astrocytes. Nature Publishing Group 2016-03-23 eng doctoral thesis VoR http://hdl.handle.net/10271/00003396 https://hama-med.repo.nii.ac.jp/records/3250 27210057 https://doi.org/10.1038/srep26427 2045-2322 Scientific Reports 6 26427 甲第764号 博士（医学） 2017-09-22 13802 浜松医科大学 https://hama-med.repo.nii.ac.jp/record/3250/files/DT_764ronbun.pdf application/pdf 2.9 MB 2018-09-13