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Photosensitizer-Induced Lipid Peroxidation in Retinal Homogenates under Illumination Hiramitsu, Tadahisa Miura, Yoshifumi Machida, Hiroyuki Copyright JCBN誌編集事務局 photosensitizers lipid peroxidation retina α-tocopherol superoxide dismutase In this study, the effect of photosensitizers on lipid peroxidation in the retina was investigated. Porcine retinal homogenate was exposed to illumination from a fluorescent lamp with or without photosensitizers such as hematoporphyrin, rose bengal, and fluorescein for 60min. The control, which was exposed to illumination without photosensitizers, did not show a significant increase in lipid peroxidation. However, lipid peroxidation in the homogenates exposed to illumination with photosensitizers increased significantly and in a dose-dependent manner. For concentrations of more than 100μM of all three photosensitizers, lipid peroxidation in the retina homogenates increased to a level approximately 2-3 times higher than that in the sample before illumination, and to a level 10 times higher than that of the control. α-Tocopherol inhibited hematoporphyrin-induced lipid peroxidation in a dose-dependent manner, but superoxide dismutase did not show an inhibitory effect. 日本酸化ストレス学会 1992-08 eng journal article VoR http://hdl.handle.net/10271/2424 https://hama-med.repo.nii.ac.jp/records/2367 10.3164/jcbn.12.109 09120009 18805086 Journal of Clinical Biochemistry and Nutrition 12 2 109 114 https://hama-med.repo.nii.ac.jp/record/2367/files/JClinBiochemNutr12-109.pdf application/pdf 607.6 kB 2018-08-27