{"created":"2023-06-20T15:45:36.296823+00:00","id":111,"links":{},"metadata":{"_buckets":{"deposit":"e3534ec6-cfa8-4d7f-8eeb-0d7d45d9b953"},"_deposit":{"created_by":4,"id":"111","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"111"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000111","sets":["1:11"]},"author_link":["321","322","323"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"【原著】","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"20","bibliographicPageStart":"14","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Acta Obstetrica et Gynaecologica Japonica","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"卵巣癌89例, 婦人科良性疾患157例及び正常者126例について血清 sialyl Tn (STN)値を測定し, 腫瘍マーカーとしての有用性を検討するとともに, 卵巣癌患者の予後と術前STN値との関係を検討した．\n1. 血清STN値は偽陽性率が正常者で4.0%, 良性疾患で9.6%と非常に低く, 卵巣癌で48.3%の陽性率を示した．臨床進行期との関係では, I期26.1%, II期33.3%, III期63.2%, IV期70.0%を示し, また, 腫瘍最大径とよく相関した．\n2. 組織型では漿液性嚢胞腺癌47.4%, 粘液性嚢胞腺癌59.3%, 類内膜癌42.9%, 類中腎癌30.0%の陽性率を示し, 陽性率及びその値とも粘液性嚢胞腺癌において高値を示したが, 他組織型の癌との間に有意差は認めなかった．Gradeとの相関は認められなかった．\n3. 術前血清STN値と卵巣癌患者の予後との関連を検討した．術前血清STN値が50.0U/ml (mean+3SD) 以上をSTN陽性例とすると, STN陽性例の1, 2, 3, 4及び5年生存率は 59.5, 29.7, 18.9, 10.8及び10.8%に対して, STN陰性例ではそれぞれ, 96.2, 92.3, 86.5, 82.7及び76.9%と有意に延長し (p<0.05), 術前STN陽性例では予後不良例が多いことが判明した．また, 1, 2, 3, 4及び5年目におけるpercent progression-freeはSTN陰性例が90.4, 86.5, 76.9, 59.6及び51.9%に対して, STN陽性例ではそれぞれ, 35.1, 16.2, 8.1, 8.1及び5.4%と有意に短縮し (p<0.05), 術前STN 陽性例では短期間に再発, 死亡していることが確認された．各進行期, 組織別及びGrade別に検討しても, STN陽性例では予後不良例が多いことが確認された．\n4. 多変量解析の結果, 患者の予後を規定する因子として血清STN値, 進行期, PS, Gradeが重要であり, STNは予後を推定する独立した因子であることが判明した．\n以上より, 卵巣癌における腫瘍マーカーのなかで, 血清STN値は specificityが高いのみならず, 卵巣癌の予後を反映するマーカーとして使用できる．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002191192","subitem_relation_type_select":"NAID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"1993047047","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-9165","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00190060","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 浩","creatorNameLang":"ja"},{"creatorName":"KOBAYASHI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺尾, 俊彦","creatorNameLang":"ja"},{"creatorName":"TERAO, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川島, 吉良","creatorNameLang":"ja"},{"creatorName":"KAWASHIMA, Yoshiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110002191192.pdf","filesize":[{"value":"628.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110002191192.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/111/files/110002191192.pdf"},"version_id":"5027f72e-6c0d-487e-b714-46a2ff93603d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sialyl Tn","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovarian cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognostic factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Progression-free interval","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Survival","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"卵巣癌患者における予後因子としての血清sialyl Tn値測定の有用性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"卵巣癌患者における予後因子としての血清sialyl Tn値測定の有用性","subitem_title_language":"ja"},{"subitem_title":"Serum Sialyl Tn Antigen as a Prognostic Marker in Patients with Epithelial Ovarian Cancer","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"111","relation_version_is_last":true,"title":["卵巣癌患者における予後因子としての血清sialyl Tn値測定の有用性"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-03-27T07:41:40.260626+00:00"}