{"created":"2023-06-20T15:45:36.548148+00:00","id":116,"links":{},"metadata":{"_buckets":{"deposit":"25ae0b88-0a09-4b71-b740-7e10e42e7c15"},"_deposit":{"created_by":4,"id":"116","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"116"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000116","sets":["1:11"]},"author_link":["341","342"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"【原著】","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"26","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Acta Obstetrica et Gynaecologica Japonica","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"頚管粘液顆粒球エラスターゼ (エラスターゼ) 活性および頚管粘液白血球数を妊娠中期の頚管ポリープ例 (N=46) と非ポリープ例 (N=53) について測定した．エラスターゼはポリープ群で86±44U/l, 非ポリープ群は22±13U/lでポリープ群が有意 (p<0.01) に高値を示した．白血球数はポリープ群1,600±450/mm^3に対し非ポリープ群は600±100/mm^3であった (p<0.05)．さらにポリープ群をポリープ切除群 (N=21) とポリープ放置群 (N=25) に分けて分析すると, 切除1週後にはエラスターゼ活性は87±49U/lから44±24U/lとなり (p<0.05), 白血球数は1,600±500/mm^3から1,150±400/mm^3となり切除前に比較し低値となった．一方放置群は診断時から1週後のエラスターゼ活性89±47U/l,白血球数1,650±450/mm^3で変化を認めなかった．\n切除したポリープをエラスターゼ抗体を用い免疫組織染色を行った．エラスターゼの染色弱陽性群の頚管粘液エラスターゼ値は46±26U/l, 陽性群は89±31U/l, 強陽性群は114±36U/lでエラスターゼの染色性の強いものほど頚管粘液エラスターゼ活性が高値を示した．また顆粒球がポリープの間質から頚管内腔へ遊走している像が散見された．頚管ポリープが存在すると頚管粘液エラスターゼ活性上昇が認められること, およびポリープに広範囲のエラスターゼの局在が見られたことから頚管ポリープは炎症のフォーカスと考えられた．\n頚管ポリープ切除によりエラスターゼ活性, 頚管内白血球数が有意に低下することが認められた．予後について絨毛羊膜炎の発生頻度は非ポリープ群では5例 (9%), ポリープ切除群では3例 (14%), ポリープ放置群では10例 (40%) であった．非ポリープ群, ポリープ切除群と比較しポリープ放置群が有意に絨毛羊膜炎の発生が高値であった．以上より, 上行感染, 絨毛羊膜炎の予防のため,妊娠中の頚管ポリープは切除あるいは局所の炎症・感染に対する治療が必要と考えられた．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002230394","subitem_relation_type_select":"NAID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"1992141328","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-9165","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00190060","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金山, 尚裕","creatorNameLang":"ja"},{"creatorName":"KANAYAMA, Naohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺尾, 俊彦","creatorNameLang":"ja"},{"creatorName":"TERAO, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"342","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110002230394.pdf","filesize":[{"value":"670.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110002230394.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/116/files/110002230394.pdf"},"version_id":"f8cd45ff-c3eb-4b60-8ea5-62c156438a54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Granulocyte elastase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cervical mucus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cervical polyp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chorioamnionitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"妊娠時頚管ポリープと頚管粘液顆粒球エラスターゼ活性との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"妊娠時頚管ポリープと頚管粘液顆粒球エラスターゼ活性との関連","subitem_title_language":"ja"},{"subitem_title":"The Relation between Granulocyte Elastase Activity in Cervical Mucus and Gestational Cervical Polyp","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"116","relation_version_is_last":true,"title":["妊娠時頚管ポリープと頚管粘液顆粒球エラスターゼ活性との関連"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-03-28T05:49:14.437759+00:00"}