{"created":"2023-06-20T15:45:36.593377+00:00","id":117,"links":{},"metadata":{"_buckets":{"deposit":"ad92cfc6-c0ac-4f25-9d50-507bbc63c926"},"_deposit":{"created_by":4,"id":"117","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"117"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000117","sets":["1:11"]},"author_link":["343","344","345"],"control_number":"117","item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"【原著】","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1174","bibliographicPageStart":"1168","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Acta Obstetrica et Gynaecologica Japonica","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的：受精卵の着床や妊娠初期の接着現象に関しては, その機序は依然として不明な点が多くいまだ十分解明されているとはいえない．そこでわれわれは, 着床直後のマウス初期胚およびヒト初期妊娠着床部, さらに正常子宮内膜培養細胞における接着関与物質の局在を酵素抗体法を用いて検索し, 初期胚と子宮内膜との接着機構の解明を試みた．\n方法：① ICR系雌マウスをPMS-hCGを用い過排卵処理し交配させ, 妊娠5日目に子宮を摘出しfibronectin (FN), laminin (LM), type IV collagen (C_<IV>), XIII因子subunit S (XIII_S)の染色を行った．② ヒト患者において手術的に摘出した卵管妊娠 (7～8w) および子宮筋腫合併妊娠 (5w) の着床部で, FN, LM, C_<IV>, XIII因子subunit A (XIII_A), XIII_Sの染色を行った．③ ヒト患者において, 手術的に摘出した筋腫子宮の正常内膜部分を無血清培地にて単層培養し, FN, XIII_A, XIII_Sの染色を行った．染色はすべて酵素抗体間接法を用いた．\n結果：① マウス初期胚着床部では, FNとXIII_Sがtrophoblast giant cellsに, C_<IV>は子宮内膜上皮細胞に陽性染色された．LMはdistal endodermとその基底膜に陽性染色された．② ヒト初期妊娠着床部ではC_<IV>がsyncytiotrophoblastの表面と絨毛間質部, および子宮又は卵管内膜間質部に, FNとXIII_Aが絨毛間質部, および子宮又は卵管内膜間質部に陽性染色された．③ 子宮内膜培養細胞においてはFNとXIII_Aが間質細胞に陽性染色された．\n結語：① マウス初期胚着床時の接着現象において, FN, C_<IV>およびそれらの接着に架橋的に働くXIII 因子の関与が強く示唆された．② ヒト初期妊娠の接着機構においてもFN, C_<IV>, XIII因子の関与が強く示唆された．③ さらにそのFNとXIII因子は, 子宮内膜間質細胞で産生されていることが判明した．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002105758","subitem_relation_type_select":"NAID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"1992141269","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-9165","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00190060","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"朝比奈, 俊彦","creatorNameLang":"ja"},{"creatorName":"ASAHINA, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小林, 隆夫","creatorNameLang":"ja"},{"creatorName":"KOBAYASHI, Takao","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺尾, 俊彦","creatorNameLang":"ja"},{"creatorName":"TERAO, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110002105758.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110002105758.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/117/files/110002105758.pdf"},"version_id":"73909449-ae36-4c92-b3fa-181ca0d7af81"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Implantation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibronectin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Laminin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Type IV collagen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Factor XIII","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"初期胚着床部における接着性物質の局在に関する免疫組織学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"初期胚着床部における接着性物質の局在に関する免疫組織学的研究","subitem_title_language":"ja"},{"subitem_title":"Studies on the Immunohistochemical Localization of Adhesive Factors at the Site of Implantation in the Early Pregnancy","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"117","relation_version_is_last":true,"title":["初期胚着床部における接着性物質の局在に関する免疫組織学的研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-03-28T06:14:28.464218+00:00"}