{"created":"2023-06-20T15:45:36.683312+00:00","id":119,"links":{},"metadata":{"_buckets":{"deposit":"3b76b7bb-770e-4c56-a8ed-378721612adb"},"_deposit":{"created_by":4,"id":"119","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"119"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000119","sets":["1:11"]},"author_link":["347","348","349","350"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"【原著】","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"726","bibliographicPageStart":"719","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Acta Obstetrica et Gynaecologica Japonica","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"従来, 胎便吸引症候群 (MAS) の診断には臨床所見, 胸部X線撮影所見とともにUrinary Meconium Index  (UMI) が用いられてきたが, UMIでは偽陽性率が高く, さらに精度の高い測定法の開発が必要であった．\nわれわれはすでに405nmの励起光に対して580nmと630nmに螢光ピークを有するZn-コプロポルフィリン (Zn-CP) が胎便中に存在し, 一方620nmに螢光ピークを有するZnを含まぬコプロポルフィリン (CP) が胎児尿や羊水中に認められることを明らかにしてきた．新生児の尿中にZn-CPの580nmの螢光ピークを検出し, そのピークの螢光強度を測定することによりMASの診断が可能かどうか検討した．その際, 従来MASの補助診断として用いられてきたUMIを模して, 新しい指標Urinary Fluorescence Meconium Index (UFMI)=F_<580>-(F_<560>+F_<600>)/2 [F:螢光強度] を定義した．I群：出生時羊水混濁を認め, 明らかに臨床的にMASと診断された症例 (n=3), II群：臨床的にMASと診断されないが, 出生時羊水混濁を認めた症例 (n=18), III群：出生時羊水混濁を認めず, 臨床的にもMASと診断されない症例 (n=25) の3群の新生児より, 生後24時間以内に尿を採取し, UFMIおよびUMIを測定し, 比較検討した．測定の結果, UMI値は3群間でオーバーラップし, 胎便成分の検出には特異的でなく, 一方UFMI値は3群間で有意差をもって解離し, 新生児の臨床症状とも一致していた．その理由はUMI では胎便成分のZn-CPとともに胎児尿成分であるCPの吸光を測定しているが, UFMIでは胎便に特異的なZn-CPのみを螢光測定している点にある．よって, UMIと比較して, UFMIがより有効なMASの診断法となることが判明した．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002105728","subitem_relation_type_select":"NAID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"1992169475","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-9165","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00190060","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"成瀬, 寛夫","creatorNameLang":"ja"},{"creatorName":"NARUSE, Hiroo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"住本, 和博","creatorNameLang":"ja"},{"creatorName":"SUMITOMO, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金山, 尚裕","creatorNameLang":"ja"},{"creatorName":"KANAYAMA, Naohiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺尾, 俊彦","creatorNameLang":"ja"},{"creatorName":"TERAO, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110002105728.pdf","filesize":[{"value":"667.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110002105728.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/119/files/110002105728.pdf"},"version_id":"dbf135f2-02a0-423b-9a90-88ed7185aeb0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Meconium Aspiration Syndrome (MAS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Urinary Meconium Index (UMI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Urinary Fluorescence Meconium Index (UFMI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"螢光を用いた胎便吸引症候群 (MAS) の特異的診断法に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"螢光を用いた胎便吸引症候群 (MAS) の特異的診断法に関する研究","subitem_title_language":"ja"},{"subitem_title":"Study on the Specific Diagnosis of Meconium Aspiration Syndrome (MAS) with Fluorometry","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"119","relation_version_is_last":true,"title":["螢光を用いた胎便吸引症候群 (MAS) の特異的診断法に関する研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-03-28T05:49:18.235656+00:00"}