{"created":"2023-06-20T15:45:36.775839+00:00","id":121,"links":{},"metadata":{"_buckets":{"deposit":"ff6ddb2b-a682-4d56-9b0e-3d738e5d74a0"},"_deposit":{"created_by":4,"id":"121","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"121"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000121","sets":["1:11"]},"author_link":["352","353","354","355","356","357","358","359","360","361"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"【原著】","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1964","bibliographicPageStart":"1959","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Acta Obstetrica et Gynaecologica Japonica","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"卵巣癌患者に対してCisplatin (以下CDDPと略す)を主体とした癌化学療法 (主にCDDP, Adriamycin, Cyclophosphamideの三剤併用化学療法, 以下PAC療法と略す) を実施し, urinastatin (以下USと略す) がCDDPによる腎障害防止に有効かどうか検討した．\nCDDPを主体とした化学療法を行った婦人科悪性腫瘍患者22例について検討し, 対象はUSを使用した12例で, その対照としてUS非使用10例について両群の腎障害の程度を比較した．1コースのPAC療法で使用した抗癌剤の量はCDDP 50mg/m^2, ADM 50mg/m^2, CPM 500mg/m^2を原則とした．USの使用方法はCDDP投与前にUS100,000単位を, CDDP投与後にはUS400,000単位を100,000?200,000単位/時間の速さで点滴静注した．総輸液量は約3,500mlで1回のPAC療法にかかる時間は7から14時間であった．なお, USを使用しなかった症例は本regimenからUSを除いて点滴を行った．\n腎障害の指標として血中BUN, Creatinine(Cr), Creatinine clearance(Ccr)値および尿中N-acetyl-β-glucosaminidase活性 (NAG), 尿中γ-glutamyl transpeptidase活性 (γ-GTP), および尿中arylamidase活性 (AA) を原則として治療前日, 投与後1, 2, 3, 7, 14および21日目に測定した．\n血中BUN, CrおよびCcr値の変化はUS使用群と非使用群の両群においてCDDP投与に伴う有意な変動は認めなかった．一方, 尿中γ-GTP, AA, NAG活性はUS使用群では経日的変化はほとんど認められなかったが, US非使用群ではいずれも一過性に上昇を示し, CDDP投与後1, 2, 3, 7, 14および21日目の尿中NAG活性は535±169, 437±153, 164±135, 198±152, 110±57, 142±84%を示した．\n以上より, USはCDDPによる腎障害抑制に極めて有効な薬剤であり, chemical nephrotoxicityをも防止し得ることが臨床的に証明された．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002228879","subitem_relation_type_select":"NAID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"1991065932","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 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Yoshiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"361","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110002228879.pdf","filesize":[{"value":"496.9 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