{"created":"2023-06-20T15:45:37.089306+00:00","id":126,"links":{},"metadata":{"_buckets":{"deposit":"b783040e-eb9d-48dc-84e6-ddbc315462d8"},"_deposit":{"created_by":4,"id":"126","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"126"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000126","sets":["1:11"]},"author_link":["385","386"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"【原著】","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1719","bibliographicPageStart":"1713","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Acta Obstetrica et Gynaecologica Japonica","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"母親にビタミンKを投与し母乳のビタミンK不足を補うことにより特発性乳児ビタミンK欠乏性出血症を予防できないかと考え以下の研究を行った．\n早期産褥婦60例をMenaquinone-4 (MK-4) 投与群, ビタミンK_1投与群, 対照群の3群に分け, 産褥4日目に採血と採乳を行い血漿中および母乳中のビタミンK_1, MK-4, MK-7濃度を測定し比較した．その結果, MK-4投与群ではMK-4濃度は血漿中2.13ng/ml, 母乳中49.3ng/mlであり, 対照群のMK-4濃度が血漿中0.28ng/ml, 母乳中1.51ng/mlであるのに比しいずれも有意に高濃度であった．またビタミンK_1投与群ではビタミンK_1の濃度が血漿中49.0ng/ml, 母乳中71.6ng/mlであり, 対照群の血漿中1.17ng/ml, 母乳中2.41ng/mlに比し有意に上昇していた．母乳中濃度を血漿中濃度で割り濃縮率と表現して比較すると, 対照群はビタミンK_1が2.52倍, MK-4が5.43倍, MK-7が0.52倍であり, MK-4投与群ではビタミンK_1が1.60倍, MK-4が40.2倍, MK-7は0.67倍となり, ビタミンK_1投与群ではビタミンK_1が1.65倍, MK-4は10.8倍, MK-7は0.71倍であった．ビタミンK_1とMK-4は母乳中に濃縮されているが濃縮率はMK-4の方が高く, ビタミンK_2 (MK-4) 製剤を投与するとさらに濃縮率が上昇した．それに対しビタミンK_1製剤を投与してもビタミンK_1の濃縮率に変化はなかった．MK-4投与群において母乳中濃度の経日的な変化を調べると, MK-4濃度は日を追うごとに上昇し, 産褥1日目の1.69ng/mlから4日目には49.3ng/mlとなり, 蓄積されて母乳中に移行しているため, MK-4を継続的に投与すると母乳中のビタミンK濃度をさらに上昇させ得ると考えられた．母親にMK-4を多く含む卵黄, 牛肉, 乳製品などを摂取するよう指導することや, 積極的にMK-4製剤を投与することは特発性乳児ビタミンK欠乏性出血症の予防法になり得ると示唆された．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002103937","subitem_relation_type_select":"NAID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"1990159267","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0300-9165","subitem_source_identifier_type":"PISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"嵯峨, こずえ","creatorNameLang":"ja"},{"creatorName":"SAGA, Kozue","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺尾, 俊彦","creatorNameLang":"ja"},{"creatorName":"TERAO, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110002103937.pdf","filesize":[{"value":"573.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110002103937.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/126/files/110002103937.pdf"},"version_id":"dd87127d-c766-4dbe-b134-0e7f057e8985"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Vitamin K","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin K deficiency","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Menaquinone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Human milk","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ビタミンKの母乳中への移行に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ビタミンKの母乳中への移行に関する研究","subitem_title_language":"ja"},{"subitem_title":"Studies on Transfer of Vitamin K into Human Breast Milk","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"126","relation_version_is_last":true,"title":["ビタミンKの母乳中への移行に関する研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-03-27T02:57:38.270072+00:00"}