{"created":"2023-06-20T15:47:07.068610+00:00","id":1654,"links":{},"metadata":{"_buckets":{"deposit":"d745bda5-2a17-4b82-b572-b1e711923932"},"_deposit":{"created_by":4,"id":"1654","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1654"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001654","sets":["1:11"]},"author_link":["3690","3691","3692","3693","3694"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"キャピラリーHPLC/FAB-MSによるヒト血漿中キノロン系抗菌剤の分析","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-12-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"175","bibliographicPageStart":"166","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"法中毒 = Japanese journal of forensic toxicology","bibliographic_titleLang":"ja"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Capillary high-performance liquid chromatography (HPLC) was combined with frit fast atom bombardment (FAB)-mass spectrometry (MS) , and a detailed procedure has been established for on-line analysis of ten quinolone antimicrobials in human plasma by the HPLC/FAB-MS. A special column switching device for concentration enabled injection of as large as a 500 μｌ sample; and the capillary column (0.5 mm i. d.) enabled introduction of its entire effluent to the frit interface of FAB-MS. These conditions gave much higher sensitivity than that of the previous HPLC/MS systems. The positive FAB mass spectra of ten quinolone carboxylic acid antimicrobials, measured with the present system, showed peaks at m/z MH, MH+H, MH+32 , MH+62 , MH+G, MH-H2O and MH-CO2 in common for most drugs. The MH+ quasi-molecular ions constituted base peaks for all drugs. Every drug, which had been spiked to human plasma, could be detected as a clean peak on mass chromatograms with sufficient sensitivity, with use of each base peak. The detection limit of this method was 0.1-0.2 μg/ml plasma for each drug, although the present method is semi-quantitative.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本法中毒学会","subitem_publisher_language":"ja"}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本法中毒学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは日本法中毒学会の許諾のもと掲載しています。","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09159606","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hattori, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seno, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Takamichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3694","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"FT-11-166.pdf","filesize":[{"value":"414.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FT-11-166.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1654/files/FT-11-166.pdf"},"version_id":"67596e9e-f23e-4f26-982f-0ccf67a9b64e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Quinolone antimicrobials","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pyridonecarboxylic acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mass spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fast atom bombardment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Liquid chromatography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Capillary HPLC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Frit FAB","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ANALYSES OF QUINOLONE ANTIMICROBIALS IN HUMAN PLASMA BY CAPILLARY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/FAST ATOM BOMBARDMENT MASS SPECTROMETRY","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ANALYSES OF QUINOLONE ANTIMICROBIALS IN HUMAN PLASMA BY CAPILLARY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/FAST ATOM BOMBARDMENT MASS SPECTROMETRY","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1654","relation_version_is_last":true,"title":["ANALYSES OF QUINOLONE ANTIMICROBIALS IN HUMAN PLASMA BY CAPILLARY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/FAST ATOM BOMBARDMENT MASS SPECTROMETRY"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T03:48:34.060271+00:00"}