{"created":"2023-06-20T15:47:09.029063+00:00","id":1691,"links":{},"metadata":{"_buckets":{"deposit":"f1ac762b-763a-420f-934e-9e02267cfbb4"},"_deposit":{"created_by":4,"id":"1691","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1691"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001691","sets":["1:11"]},"author_link":["3897","3898","3899","3900","3901","3902","3903"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"SENSITIVE DETERMINATION OF GENERAL ANAESTHETICS IN HUMAN WHOLE BLOOD BY CAPILLARY GAS CHROMATOGRAPHY WITH CRYOGENIC OVEN TRAPPING","subitem_alternative_title_language":"en"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-05-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"135","bibliographicPageStart":"134","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"法中毒","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese journal of forensic toxicology","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Halothane, enflurane, isoflurane and sevoflurane are widely used as general anaesthetics. Their toxic concentrations are only 2 - 4 times higher compared to their therapeutic concentrations, and their abusers are frequently reported. Thus sensitive determinations for these anaesthetics must be important. In this presentation, we have applied cryogenic oven trapping for determining above four general anaesthetics in human whole blood samples. A 0.5-ml human whole blood with or without anaesthetics was added to a 7-ml vial containing 0.48 ml of distilled water and 0.02 ml of 10 % Triton X-100 solution (containing 5 μg internal standard), and the mixture was heated at 55°C for 15 min. A 10-ml headspace vapor was introduced into a GC capillary column in the splitless mode at -40°C oven temperature, that was programmed up to 250°C for GC analysis with flame ionization detection. All four peaks of the anaesthetics were clearly separated, and the backgrounds were very clean. Their extraction efficiencies were 8.3 - 15.3 %. The calibration curves showed good linearity in the range of 0.5 - 20 μg/ml and the determination limits were 20 100 ng/ml, which were comparable to previous GC-mass spectrometric (MS) and GC-Fourier transform infrared spectroscopy (FTIR) methods. Our present method should be useful for forensic toxicology; it can be also rapid monitoring for their anaesthetics in the human blood.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本法中毒学会","subitem_publisher_language":"ja"}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本法中毒学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは日本法中毒学会の許諾のもと掲載しています。","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09159606","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小嶋, 高志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石井, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"勝又, 義直"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 加奈子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"妹尾, 洋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 修"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"熊澤, 武志"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"FT-18-134.pdf","filesize":[{"value":"111.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FT-18-134.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1691/files/FT-18-134.pdf"},"version_id":"96d0fa76-15cd-49b2-89d4-876ee86315af"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低温オーブントラッピングキャピラリーガスクロマトグラフィーによるヒト血中全身麻酔薬の高感度分析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低温オーブントラッピングキャピラリーガスクロマトグラフィーによるヒト血中全身麻酔薬の高感度分析","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1691","relation_version_is_last":true,"title":["低温オーブントラッピングキャピラリーガスクロマトグラフィーによるヒト血中全身麻酔薬の高感度分析"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T04:00:08.928858+00:00"}