{"created":"2023-06-20T15:47:09.211237+00:00","id":1695,"links":{},"metadata":{"_buckets":{"deposit":"42029439-25d4-472c-996a-6b6fef2ef24e"},"_deposit":{"created_by":4,"id":"1695","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1695"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001695","sets":["1:11"]},"author_link":["3920","3921","3922","3923","3924","3925","3926","3927"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヘッドスペース固相マイクロ抽出を用いた全血中ガンマヒドロキシ酪酸（GHB）の簡便抽出法","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"45","bibliographicPageStart":"38","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"法中毒","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese journal of forensic toxicology","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have developed a simple method for the extraction of gamma-hydroxybutyrate (GHB) in human whole blood using headspace solid-phase microextraction (SPME). The procedure involves the conversion of GHB to gamma-butyrolactone (GBL) with acid catalysis; gamma-valerolactone (GVL) was used as internal standard (IS). After heating a vial containing a whole blood sample with GHB and IS at 80℃ for 5 min in the presence of H3PO4 solution, a Carboxen/polydimethylsiloxane -coated fiber was exposed to the headspace to allow adsorption of GBL and IS. The fiber needle was then injected into a capillary gas chromatography port. Although the extraction efficiency of GHB was no more than 0.68%, the calibration curve showed good linearity in the range of 10-200μg/ml, and intra-day and inter-day assay coefficients of variation were 3.29 and 4.14%, respectively. The detection limit was about 2μg/ml. The present SPME method for GHB is sensitive enough to be adopted in forensic toxicology and clinical pharmacology .","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本法中毒学会","subitem_publisher_language":"ja"}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本法中毒学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは日本法中毒学会の許諾のもと掲載しています。","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09159606","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kurihara, Rina"}],"nameIdentifiers":[{"nameIdentifier":"3920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Akira"}],"nameIdentifiers":[{"nameIdentifier":"3921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Kanako"}],"nameIdentifiers":[{"nameIdentifier":"3922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumazawa, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"3923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seno, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"3924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"3925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsumata, Yoshinao"}],"nameIdentifiers":[{"nameIdentifier":"3926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kanako"}],"nameIdentifiers":[{"nameIdentifier":"3927","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"FT-19-38.pdf","filesize":[{"value":"382.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FT-19-38.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1695/files/FT-19-38.pdf"},"version_id":"c3a90624-6257-45c0-af7f-7f9b219aaec3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Solid-phase microextraction","subitem_subject_scheme":"Other"},{"subitem_subject":"Headspace method","subitem_subject_scheme":"Other"},{"subitem_subject":"Gas chromatography","subitem_subject_scheme":"Other"},{"subitem_subject":"Gammahydroxybutyrate","subitem_subject_scheme":"Other"},{"subitem_subject":"Gamma-butyrolactone","subitem_subject_scheme":"Other"},{"subitem_subject":"Gamma-valerolactone","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SIMPLE EXTRACTION OF GAMMA-HYDROXYBUTYRATE IN HUMAN WHOLE BLOOD BY HEADSPACE SOLID-PHASE MICROEXTRACTION","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SIMPLE EXTRACTION OF GAMMA-HYDROXYBUTYRATE IN HUMAN WHOLE BLOOD BY HEADSPACE SOLID-PHASE MICROEXTRACTION","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1695","relation_version_is_last":true,"title":["SIMPLE EXTRACTION OF GAMMA-HYDROXYBUTYRATE IN HUMAN WHOLE BLOOD BY HEADSPACE SOLID-PHASE MICROEXTRACTION"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T04:00:20.254192+00:00"}