@article{oai:hama-med.repo.nii.ac.jp:00001704,
 author = {有信, 哲哉 and 服部, 秀樹 and 岩井, 雅枝 and 妹尾, 洋 and 石井, 晃 and 熊澤, 武志 and 鈴木, 修},
 issue = {2},
 journal = {法中毒, Japanese journal of forensic toxicology},
 month = {May},
 note = {We have developed a rapid determination method for local anesthetics of tetracaine, procaine, benzoxinate, dibucaine, lidocaine, bupivacaine and mepivacaine by high-performance liquid chromatography (HPLC)-mass spectrometry (MS) coupled with a diol-bonded silica gel HPLC column that enabled direct injection of biological samples. We have also compared the sensitivities for the drags by sonic spray ionization (SSI) and atmospheric pressure chemical ionization (APCI). Those by HPLC-SSI-MS for tetracaine, benzoxinate, dibucaine, bupivacaine and mepivacaine were 4, 16, 16, 8 and 4 times higher, respectively. Those by HPLC-SSI-MS for procaine and lidocaine were equivalent to those by HPLC-APCI-MS. From a synthetic view, the simultaneous analysis of local anesthetics by HPLC-SSI-MS seems to be better than HPLC-APCI-MS.},
 pages = {210--211},
 title = {局所麻酔薬8種のHPLC-MSによる分離分析法とSSI及びAPCI法の感度比較},
 volume = {20},
 year = {2002}
}