{"created":"2023-06-20T15:47:10.570595+00:00","id":1716,"links":{},"metadata":{"_buckets":{"deposit":"7fa37d27-1579-482e-aecf-d14f34908a7d"},"_deposit":{"created_by":4,"id":"1716","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1716"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001716","sets":["1:11"]},"author_link":["4055","4056","4057","4058","4059","4060"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ポリマーカラムを用いた全血中ブチロフェノン系薬物のLC/MS/MS分析","subitem_alternative_title_language":"ja"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"17","bibliographicPageStart":"13","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"法中毒","bibliographic_titleLang":"ja"},{"bibliographic_title":"Japanese journal of forensic toxicology","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Seven butyrophenones in human whole blood were analyzed by LC/MS/MS using a new polymer column (MSpak GF-310), which enabled direct injection of crude biological samples without complicated pretreatments. The quantitation was made by mass chromatography for each product ion, The recoveries were more than 50% for haloperidol, bromperidol, moperone and spiroperidol at 80 ng/ml in whole blood, but less than 10% for pimozide. The regression equations showed good linearity for haloperidol, bromperidol, moperone and spiroperidol in the range of 10-80 ng/ml, for timiperone in the range of 20-80 ng/ml and for pimozide in the range of 50-200 ng/ml using the chlorinated analog of haloperidol as internal standard, Their detection limits were about 5 ng/ml for haloperidol, bromperidol, moperone and spiroperidol, about 10 ng/ml for timiperone and about 25 ng/ml for pimozide. Thus, the present method seems useful for sensitive and specific detection and determination of their high therapeutic and toxic levels present in biological specimens including whole blood.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本法中毒学会","subitem_publisher_language":"ja"}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本法中毒学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは日本法中毒学会の許諾のもと掲載しています。","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09159606","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hattori, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"4055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arinobu, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"4056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwai, Masae"}],"nameIdentifiers":[{"nameIdentifier":"4057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masuda, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"4058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"4059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seno, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"4060","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"FT-23-13.pdf","filesize":[{"value":"329.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FT-23-13.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1716/files/FT-23-13.pdf"},"version_id":"00c42faf-32ca-43ea-9e66-2847dafd0275"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Butyrophenones","subitem_subject_scheme":"Other"},{"subitem_subject":"Haloperidol","subitem_subject_scheme":"Other"},{"subitem_subject":"Bromperidol","subitem_subject_scheme":"Other"},{"subitem_subject":"Moperone","subitem_subject_scheme":"Other"},{"subitem_subject":"Spiroperidol","subitem_subject_scheme":"Other"},{"subitem_subject":"LC/MS/MS","subitem_subject_scheme":"Other"},{"subitem_subject":"New polymer column (MSpak GF-310)","subitem_subject_scheme":"Other"},{"subitem_subject":"Whole blood","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ANALYSIS OF BUTYROPHENONES IN WHOLE BLOOD SPECIMENS BY LC/MS/MS USING A NEW POLYMER COLUMN","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ANALYSIS OF BUTYROPHENONES IN WHOLE BLOOD SPECIMENS BY LC/MS/MS USING A NEW POLYMER COLUMN","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1716","relation_version_is_last":true,"title":["ANALYSIS OF BUTYROPHENONES IN WHOLE BLOOD SPECIMENS BY LC/MS/MS USING A NEW POLYMER COLUMN"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T04:01:10.670981+00:00"}