{"created":"2023-06-20T15:47:10.891371+00:00","id":1723,"links":{},"metadata":{"_buckets":{"deposit":"4b64eca9-04cd-42a7-aa79-38f3a09538de"},"_deposit":{"created_by":2,"id":"1723","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"1723"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001723","sets":["1:11"]},"author_link":["4105","4103","4106","4111","4109","4110","4107","4108","4104","4102"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Rapid and simple determination of selective serotonin reuptake inhibitor (SSRI) in human serum or plasma by LC/MS and LC/MS/MS"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"163","bibliographicPageStart":"162","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"法中毒 = Japanese journal of forensic toxicology"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A sensitive, simple and rapid method using LC/MS and LC/MS/MS assay for selective serotonin reuptake inhibitors (SSRIs), in human serum or plasma was investigated in this study. In this method, three SSRIs, paroxetine, sertraline and fluvoxamine were measured; dextromethorphan was used as internal standard (IS). Serum or plasma samples with or without the compounds and IS, which were mixed with formic acid, were directly subjected to LC/MS. In MS spectra, [M + 1]- ions for paroxetine and fluvoxamine, [M - 31]- ion for sertraline were observed as base peaks. For MS/MS analyses, [M + 1] -ions of the compounds were used as precursor ions for these identification and quantitation. The three compounds could be identified above 100 ng/ml serum, using MS and dependent MS/MS. For three compounds, the calibration curves were linear in the range 5 - 80 ng/ml in the serum and the detection limits were under 5 ng/ml serum and 10 ng/ml plasma, respectively. These results indicate that this presented method can be useful to determine the SSRI in human serum or plasma.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本法中毒学会"}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 日本法中毒学会"},{"subitem_rights":"本文データは日本法中毒学会の許諾のもと掲載しています。"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09159606","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"服部, 秀樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 健次郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岩井, 雅枝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"益田, 健史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"水谷, 洋子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"妹尾, 洋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"有信, 哲哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"熊澤, 武志"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石井, 晃"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 修"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"FT-23-162.pdf","filesize":[{"value":"128.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FT-23-162.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1723/files/FT-23-162.pdf"},"version_id":"2398ac30-0ef4-4705-a83e-3ee8b7fe8928"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"選択的セロトニン再吸収抑止物質（SSRI）のLC/MSならびにLC/MS/MSによる迅速測定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"選択的セロトニン再吸収抑止物質（SSRI）のLC/MSならびにLC/MS/MSによる迅速測定"}]},"item_type_id":"3","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1723","relation_version_is_last":true,"title":["選択的セロトニン再吸収抑止物質（SSRI）のLC/MSならびにLC/MS/MSによる迅速測定"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-06-20T17:31:46.170511+00:00"}