{"created":"2023-06-20T15:47:19.733835+00:00","id":1869,"links":{},"metadata":{"_buckets":{"deposit":"12108ac3-890b-402e-9a35-72edfda84e7b"},"_deposit":{"created_by":4,"id":"1869","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1869"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001869","sets":["1:11"]},"author_link":["4715","4716","4717","4718","4719"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"25","bibliographicPageEnd":"2629","bibliographicPageStart":"2624","bibliographicVolumeNumber":"877","bibliographic_titles":[{"bibliographic_title":"Journal of Chromatography B","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inorganic arsenic species are metabolized to monomethylarsonic acid (MMA V) and dimethylarsinic acid (DMA V) and excreted into urine. A simple, rapid and sensitive method has been developed using electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the simultaneous determination of MMA V and DMA V. MMA V and DMA V in a sample were allowed to react with citric acid (CiA). Adduct compounds were extracted together with isoamyl alcohol (IAA). An aliquot (1-μL) of the IAA layer was directly injected into the ESI-MS-MS instrument, and was detected within 1 min. Quantification was done using selected reaction monitoring for MMA V and DMA V as follows.  [MMAH + 2CiA - 3H2O]+ → [MMAH + CiA - 2H2O]+   [DMAH + CiA + MeOH - 2H2O]+ → [DMAH + MeOH - H2O]+  Where, MMAH and DMAH denote the protonated forms of MMA V and DMA V, and MeOH denotes methanol (carrier liquid in ESI-MS-MS). This method was validated for the analysis of urine samples. The limit of detection of As was 0.3 μgL-1 for MMA V and 0.6 μgL-1 for DMA V using 10 μL of sample solution. Results were obtained in <10 min with a linear calibration range of 3-100 μgL-1. Inorganic arsenic compounds (and other organic arsenic compounds) found in urine did not interfere with the detection of MMA V and DMA V. Concentrations of MMA V and DMA V in the reference urine SRM 2670a were estimated after partial purification, and those in urine of a patient treated with As2O3 were measured after dilution.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jchromb.2009.03.016","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2009 Elsevier B.V.","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15700232","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Minakata, Kayoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohnishi, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Satoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4719","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JofC_B-877-2624.pdf","filesize":[{"value":"517.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JofC_B-877-2624.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1869/files/JofC_B-877-2624.pdf"},"version_id":"ad8796f8-ee0a-47de-b248-ee2acb2ff423"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Monomethylarsonic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dimethylarsinic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tandem mass spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Electrospray ionization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Citric acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adduct","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Electrospray ionization tandem mass spectrometric determination of monomethylarsonic acid and dimethylarsinic acid after adduct formation with citric acid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Electrospray ionization tandem mass spectrometric determination of monomethylarsonic acid and dimethylarsinic acid after adduct formation with citric acid","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1869","relation_version_is_last":true,"title":["Electrospray ionization tandem mass spectrometric determination of monomethylarsonic acid and dimethylarsinic acid after adduct formation with citric acid"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T02:08:00.614927+00:00"}