{"created":"2023-06-20T15:47:20.250855+00:00","id":1876,"links":{},"metadata":{"_buckets":{"deposit":"49e085ef-02b7-4760-be67-456935c9d054"},"_deposit":{"created_by":4,"id":"1876","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1876"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001876","sets":["1:11"]},"author_link":["4773","4774","4775","4776","4777"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"R212","bibliographicPageStart":"R208","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Arthritis Research & Therapy","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49-85 years with knee OA were studied. Anterior-posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups: 37 patients exhibiting generalized osteoarthritis (GOA) and 34 non-GOA patients, according to the grading of their hand radiograph. C-reactive protein (CRP), urinary pyridinoline, YKL-40, plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of arthritis. The radiographic grading with the Kellgren-Lawrence scale revealed a significant relationship to the joint space width (P = 0.003): the joint space width decreased with increasing Kellgren-Lawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation (P = 0.039). Pyridinoline (P = 0.034) and TIMP-1 (P = 0.017) also exhibited a significant relationship to the Kellgren-Lawrence grade. In GOA evaluations, the joint space width did not differ between GOA and non-GOA patients. CRP, pyridinoline, YKL-40 and MMP-3 levels were significantly greater in GOA patients than in non-GOA patients. CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type of radiographic grading examined in the present study.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd","subitem_publisher_language":"en"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/ar1166","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright BioMed Central Ltd","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14786354","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Masaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4773","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naito, Kenichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4774","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Masashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4775","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawada, Tomokazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagano, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4777","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"ar-2004_6-208.pdf","filesize":[{"value":"154.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ar-2004_6-208.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1876/files/ar-2004_6-208.pdf"},"version_id":"68fbaadb-c454-4f80-9426-9191d545adfb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"generalized osteoarthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"markers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"osteoarthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radiographic grading","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1876","relation_version_is_last":true,"title":["Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T02:08:16.924666+00:00"}