{"created":"2023-06-20T15:47:20.608924+00:00","id":1881,"links":{},"metadata":{"_buckets":{"deposit":"268b993b-a1ab-4dde-bb49-200f8be95912"},"_deposit":{"created_by":4,"id":"1881","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1881"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001881","sets":["1:11"]},"author_link":["4831","4832","4833","4834","4835","4836","4837","4838"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"131","bibliographicPageStart":"123","bibliographicVolumeNumber":"147","bibliographic_titles":[{"bibliographic_title":"Journal of Surgical Research ","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background. A n increase of leaky vasculature is vital for the growth and metastasis of hepatocellular carcinoma (HCC). The paracellular permeability-regulating proteins in tumor vessels and adjacent sinusoids have not been studied in HCC patients. Methods. Expression of an endothelial tight junction protein claudin-5 (CL-5) and a standard endothelial marker CD34 were immunohistochemically examined in resected specimens from 51 HCC cases. The relationship between hepatitic or fibrotic grade and CL-5 expression pattern in sinusoidal endothelial cells (SECs) was evaluated in the tumor-adjacent tissues. Microvessel density (MVD) highlighted by CD34 or CL-5 was examined in tumor tissues. Results. In the normal liver, a ubiquitous CL-5 expression was seen in SECs, the arteries, and portal veins but not in the central veins. Sinusoidal CL-5 expression was down-regulated according to the increase of hepatitic or fibrotic grade. Poor differentiation and vasculobiliary invasion were significantly associated with a lower CL-5-MVD but not CD34-MVD. By multivariate analysis, vasculobiliary invasion and lower CL-5-MVD were independent factors associated with a lower postoperative overall survival rate. Conclusions. Attenuated CL-5 expression in SECs may be related to SEC dysfunction in injured liver. Down-regulated CL-5 expression in tumor vessels may serve as a potential marker for poor prognosis in HCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jss.2007.07.013","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2008 Elsevier Inc","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00224804","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"10958673","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakaguchi, Takanori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Shohachi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inaba, Keisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Baba, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konno, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4838","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"J_Surg_Res-147-123.pdf","filesize":[{"value":"656.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"J_Surg_Res-147-123.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1881/files/J_Surg_Res-147-123.pdf"},"version_id":"028fdb6c-7a9b-4efd-9200-107345b01e36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tight junction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"claudin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sinusoid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"angiogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microvessel density","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma.","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1881","relation_version_is_last":true,"title":["Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma."],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T02:08:34.704186+00:00"}