{"created":"2023-06-20T15:47:24.382559+00:00","id":1942,"links":{},"metadata":{"_buckets":{"deposit":"868e5ee1-4fcf-4925-9ade-f9009d5f7d5e"},"_deposit":{"created_by":4,"id":"1942","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1942"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001942","sets":["1:11"]},"author_link":["4934"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"396","bibliographicPageStart":"390","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"子宮内膜症および子宮筋腫患者腹水中のCA125濃度を比較し, 子宮内膜組織由来CA125抗原の腹水中濃度に及ぼす影響を検討するとともに家兎を用い腹水中CA125抗原の末梢血中への移行動態を調べた。1. 子宮筋腫および子宮内膜症患者の腹水中CA125濃度は両者とも有意差を認めないが, 月経期にやや高値を示した。2. 子宮および卵巣を摘出された患者の腹水中にも高濃度のCA125抗原が検出された。3. 子宮腺筋症患者では摘出子宮重量と腹水中CA125濃度はr=0.321と相関は認められなかった。4. 子宮内膜症の保存療法中の血中, 腹水中CA125濃度の変化を経時的に測定すると, ダナゾール投与中は血中, 腹水中濃度は漸減するが, 投与終了後は約2カ月で腹水中濃度は投与前値に上昇し, 血中濃度の推移と解離した。5. 卵巣癌患者で腹膜播種の有無による腹水中および血中CA125濃度を比較すると, 腹膜播種を認めた症例はど腹水中および血中濃度は高値を示した。6. 家兎腹膜をCH_3COOHにより人為的にchemical peritonitisを作成し, 血中へのCA125の移行動態を調べると, 腹膜の組織破壊が高度になるにつれて血中への移行は不良となり, 腹膜炎の程度と腹膜より血中への移行率には反比例の関係が得られた。以上より, 子宮内膜組織由来CA125は子宮腺筋症の場合は血中へは比較的鋭敏に反映し高CA125血症を呈しやすいが, 腹水中CA125濃度にはほとんど影響を与えず, 正所子宮内膜の存在が腹水中濃度に若干関与しているものの, 子宮内膜以外, 例えば, 正常腹膜等にも腹水中CA125の由来を求める必要がある。また, 腹膜の生理的機能の破綻がperitoneal clearanceの低下を介して腹水中濃度の上昇をきたすものと考えられる。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03009165","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"4934","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"sankafujinka-41_4-390.pdf","filesize":[{"value":"674.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"sankafujinka-41_4-390.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1942/files/sankafujinka-41_4-390.pdf"},"version_id":"6fed9331-4dd1-4836-a202-894ddd621f32"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CA125","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endometriosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovarian cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peritoneum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peritonitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"腹水中CA125抗原の由来および血中への移行動態に関する基礎的・臨床的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腹水中CA125抗原の由来および血中への移行動態に関する基礎的・臨床的検討","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1942","relation_version_is_last":true,"title":["腹水中CA125抗原の由来および血中への移行動態に関する基礎的・臨床的検討"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:20:15.062299+00:00"}