{"created":"2023-06-20T15:47:24.544200+00:00","id":1945,"links":{},"metadata":{"_buckets":{"deposit":"0787ce9a-8577-4f7f-b5c8-cb6a54e49a98"},"_deposit":{"created_by":4,"id":"1945","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1945"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001945","sets":["1:11"]},"author_link":["4937"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"834","bibliographicPageStart":"828","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2型糖鎖抗原に属するSialyl SSEA-1抗原を用いて婦人科疾患, 特に卵巣癌に対する腫瘍マーカーとしての有用性について検討するとともに, CA125との関連についても検討した. 子宮筋腫, 子宮内膜症, 良性卵巣腫瘍患者の平均値±標準偏差および陽性率は, 28.5±12.2U/ml(16.1%), 33.2±13.5U/ml (31.3%)および30.0±30.3U/ml (11.6%)であり, 子宮内膜症患者に比較的高い陽性率を認めた. 卵巣癌患者の臨床進行期別にその平均値±標準偏差および陽性率を求めると, I期は28.9±15.3U/ml(20.1%), II期は45.3±30.7U/ml(43.8%), III期は182.3±643.3U/ml(50.0%)およびIV期は63.2±70.4U/ml (72.2%)とその陽性率は臨床進行期が進むにつれて上昇した. また, 治療経過に伴うSialyl SSEA-1の変動は予後とよく相関した. CA125とのコンビネーションアッセイでは, Sialyl SSEA-1陽性でCA125陰性例は1例しか存在しなかつた. しかし, CA125と異なり, Sialyl SSEA-1は妊娠による影響が少ないため, 卵巣腫瘍合併妊娠における有用性はCA125より優れていた. 一方, 各種疾患腹水中や体液中のSialyl SSEA-1濃度を測定した結果, CA125と同様にチョコレート嚢胞内容液, 羊水中および卵巣癌患者腹水中に極めて高濃度の抗原が存在した. さらに, 子宮内膜症患者の腹水中濃度も比較的高値を示すため, これが血中濃度に反映している可能性が示唆された. 以上より, Sialyl SSEA-1抗原はCA125と同様, 子宮内膜症で比較的高値を示す傾向を認めたが, その陽性率はCA125より低率であつた. また, 卵巣癌の血清学的診断における有用性に関しては, 卵巣癌全体では47.2%に陽性を認め, 臨床的には予後をよく反映したが, 早期癌における陽性率が低く, 早期発見には不適当であつた. さらにCA125とのオーバーラップを認めたため, コンビネーションアッセイによる陽性率の上昇は期待できなかつた","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002113191","subitem_relation_type_select":"NAID"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03009165","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"4937","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"sankafujinka-40_7-828.pdf","filesize":[{"value":"637.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"sankafujinka-40_7-828.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1945/files/sankafujinka-40_7-828.pdf"},"version_id":"fdccc145-7476-4eb5-b0f9-bd6a1579c410"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sialyl SSEA-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CA125","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ovarian cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endometriosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"婦人科疾患におけるSialyl SSEA-1測定の臨床的有用性 : 特にCA125との関連について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"婦人科疾患におけるSialyl SSEA-1測定の臨床的有用性 : 特にCA125との関連について","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1945","relation_version_is_last":true,"title":["婦人科疾患におけるSialyl SSEA-1測定の臨床的有用性 : 特にCA125との関連について"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:20:22.341292+00:00"}