{"created":"2023-06-20T15:47:24.587926+00:00","id":1946,"links":{},"metadata":{"_buckets":{"deposit":"c025d9e7-546a-401f-8f1d-36b23c4aa1ea"},"_deposit":{"created_by":4,"id":"1946","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"1946"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00001946","sets":["1:11"]},"author_link":["4938"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"159","bibliographicPageStart":"153","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"日本産科婦人科學會雜誌","bibliographic_titleLang":"ja"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"外来維持強化化学療法としてのPAC療法に伴う消化器症状を抑制するために, プリンペラン, オルガドロン, クロルトリメトンの3剤併用を試み, その制吐効果をrandomized parallel studyにより検討した. 1. 今回使用した制吐剤は, 化学療法当日がプリンペラン(1mg/kg, 2.5時間毎, 4回), オルガドロン(5mg, 2.5時間毎, 4回), クロルトリメトン(10mg, 5時間毎, 2回)であり, 5日間で漸減した. 2. 1回目のPAC療法を施行した場合の制吐剤併用の検討 化学療法当日の悪心の程度は, 制吐剤併用群で改善したが, delayed persistant nauseaは両者ともに同程度認められた. 化学療法当日の嘔吐回数は制吐剤併用群で1.6回, 非併用群で8.9回と著明な改善を認めた. 嘔吐量も同様に前者102mlに対して後者352mlであつた. 3. 2回目以降のPAC療法を施行した場合の制吐剤併用の効果 悪心の程度は1回目にくらべて制吐剤非併用群で遷延し, anticipatory nauseaの影響が考えられた. 嘔吐回数および嘔吐量は制吐剤併用群2.1回, 78mlに対し, 非併用群は7.9回, 341mlであつた. 4. 維持強化化学療法中の社会復帰の状況 制吐剤非併用群では, 化学療法施行1～2週間後に社会復帰の低下を認めたが, 4週間以降では化学療法前と同程度に回復した. 一方, 制吐剤併用群では2週間目に回復徴候を認めた. 以上より, PAC療法に伴うacute drug-induced emesisはプリンペラン, オルガドロン, クロルトリメトンで充分抑制された. PAC療法2回目以降の場合では1回目にくらべてdelayed persistant nausea が遷延した. しかし, 今回検討したPAC療法ではもともとdelayed persistant emesisが著明でなかつたため, この検討は今後の問題である. なお, 制吐剤を併用すればPAC療法2週間で社会復帰は充分可能であるが, 骨髄抑制を考慮し, PAC療法後3週間は安静を保つ必要があると思われる.","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110002112882","subitem_relation_type_select":"NAID"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本産科婦人科学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03009165","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 浩","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"4938","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"sankafujinka-40_2-153.pdf","filesize":[{"value":"618.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"sankafujinka-40_2-153.pdf","url":"https://hama-med.repo.nii.ac.jp/record/1946/files/sankafujinka-40_2-153.pdf"},"version_id":"d1a51f3d-0363-4513-9e99-055590ce6b0b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Antiemesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cis-diamminedichloroplatinum","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PAC療法における消化器症状に対するmetoclopramide, dexamethasone, antihistamine 3剤併用の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PAC療法における消化器症状に対するmetoclopramide, dexamethasone, antihistamine 3剤併用の効果","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"1946","relation_version_is_last":true,"title":["PAC療法における消化器症状に対するmetoclopramide, dexamethasone, antihistamine 3剤併用の効果"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:20:24.813576+00:00"}