{"created":"2023-12-12T01:42:32.442698+00:00","id":2000055,"links":{},"metadata":{"_buckets":{"deposit":"e5c828ee-8bc0-4f79-8504-4b37ab5eb5e4"},"_deposit":{"created_by":4,"id":"2000055","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000055"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000055","sets":["1:11"]},"author_link":[],"control_number":"2000055","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"319","bibliographicPageStart":"314","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Ophthalmology","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose  Chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial disease characterized by slowly progressive ptosis and limitations in ocular motility. Although exophthalmos is not considered to be a common feature of CPEO, this study focused on the incidence of exophthalmos in patients with CPEO.\nStudy design  Retrospective observational case series\nMethods  We reviewed the clinical charts of patients who received a diagnosis of CPEO sometime during the period between January 2010 and December 2018. CPEO was diagnosed on the basis of detection of a deletion of mitochondrial DNA (mtDNA) from saliva, buccal mucosa, or extraocular muscle specimens obtained during strabismus surgery. Horizontal MRI/CT images or Hertel ophthalmometry was used in determining exophthalmos.\nResults  Seven patients (4 males) were identified. The mean age at diagnosis was 32.6 years (range, 13-53 years). mtDNA deletion mutations were detected in the buccal mucous membrane DNA in 5 patients and in the saliva and extraocular muscle DNA in 2 patients. MRI/CT was recorded in 6 patients, four of whom showed exophthalmos (cases 1-4), and case 5 was determined as exophthalmos on the basis of a Hertel ophthalmometer reading.\nExophthalmos was bilateral in 4 of the patients (cases 1, 2, 4, and 5) and unilateral in 1 patient (case 3). Exophthalmos was the chief concern of 2 of the patients; however, it was not clinically significant in the other patients.\nConclusions  Although exophthalmos may not be recognized by either the patient or the clinician, it may be one of the common features of CPEO. A large multiethnic study should be performed.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"日本眼科学会","subitem_publisher_language":"ja"},{"subitem_publisher":"Japanese Ophthalmological Society","subitem_publisher_language":"en"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"35438395","subitem_relation_type_select":"PMID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"2023145645","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s10384-022-00920-5","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10384-022-00920-5","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-5155","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1613-2246","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00691177","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeda, Yu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hosono, Katsuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hikoya, Akiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Komori, Miwa","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inagaki, Risako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Haseoka,Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Arai, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takagi, Yuri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hotta, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Miho","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-11"}],"displaytype":"detail","filename":"JJO-66-314.pdf","filesize":[{"value":"1199 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000055/files/JJO-66-314.pdf"},"version_id":"aef82614-20b0-4438-891c-e6d9916561ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Exophthalmos","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chronic progressive external ophthalmoplegia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Strabismus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Exophthalmos associated with chronic progressive external ophthalmoplegia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Exophthalmos associated with chronic progressive external ophthalmoplegia","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-11"},"publish_date":"2023-12-11","publish_status":"0","recid":"2000055","relation_version_is_last":true,"title":["Exophthalmos associated with chronic progressive external ophthalmoplegia"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-12-18T01:57:57.725793+00:00"}