{"created":"2023-12-21T07:45:09.389356+00:00","id":2000061,"links":{},"metadata":{"_buckets":{"deposit":"ec6b73d1-f602-46d1-b9fd-d0a60e18fcac"},"_deposit":{"created_by":4,"id":"2000061","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000061"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000061","sets":["1:11"]},"author_link":[],"control_number":"2000061","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"464","bibliographicPageStart":"457","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Organic Preparations and Procedures Internationa","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載タイトル：Facile Multi-gram Preparation of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Carcinogenic benzo[a]pyrene diol epoxide (BPDE) is one of the essential materials in tumor pathological research; however, it is expensive and unstable. In addition, its synthetic intermediates are metabolic intermediates of BPDE; thus, there is a need to reduce the handling of these compounds during the synthesis. Accordingly, a precursor of BPDE (i.e., trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene) was prepared in a multi-gram scale by modified procedures. Efficient work-ups (e.g., simple extraction and precipitation) were also improved, which resulted in a crude product with high target compound content in each step of the synthesis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/00304948.2022.2081026","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Accepted Manuscript of an article published by Taylor & Francis in Organic Preparations and Procedures Internationa on 2022, available at: https://doi.org/10.1080/00304948.2022.2081026.","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0030-4948","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1945-5453","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00765353","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kurono, Nobuhito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwashita, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugimura, Haruhiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-12-21"}],"displaytype":"detail","filename":"OPPI-54-457.pdf","filesize":[{"value":"304 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000061/files/OPPI-54-457.pdf"},"version_id":"12c8a630-bc23-4697-bd2b-fa251f728d9a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"facile preparation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multi-grams synthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BPDE","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"carcinogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thermal instability","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Facile Preparation of Multi-grams of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Facile Preparation of Multi-grams of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-25"},"publish_date":"2023-12-25","publish_status":"0","recid":"2000061","relation_version_is_last":true,"title":["Facile Preparation of Multi-grams of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-12-27T01:22:11.155725+00:00"}