{"created":"2024-02-02T05:05:05.084748+00:00","id":2000079,"links":{},"metadata":{"_buckets":{"deposit":"8656204e-b55c-42eb-9a16-bbc09445ecf2"},"_deposit":{"created_by":4,"id":"2000079","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000079"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000079","sets":["1:11"]},"author_link":[],"control_number":"2000079","item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"PSL and TAC treatment in PM/DM-ILD","subitem_alternative_title_language":"en"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"377","bibliographicPageStart":"370","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Respirology","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載タイトル：Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis/dermatomyositis-associated ILD: A randomized, open-label trial","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Objective\nThe efficacy of combination therapy with corticosteroids and calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A (CsA), for polymyositis/dermatomyositis-associated interstitial lung diseases (PM/DM-ILD) has been described retrospectively. However, it remains unknown which CNIs treatment regimens, TAC or CsA regimens, are more effective as initial treatments for patients with PM/DM-ILD.\nMethods\nWe conducted a prospective multicenter, open-label, randomized, 52-week phase 2 trial. Patients with PM/DM-ILD were randomly allocated to receive prednisolone (PSL) plus TAC (TAC group) or PSL plus CsA (CsA group). The primary endpoint was progression-free survival (PFS) rate in the intention-to-treat population at 52 weeks. The secondary endpoints were overall survival (OS) rate at 52 weeks, changes in pulmonary function tests from baseline to 52 weeks, and adverse events (AEs).\nResults\nFifty-eight patients were randomly assigned to the TAC group (n=30) and the CsA group (n=28). The PFS rates at 52 weeks were 87% in the TAC group and 71% in the CsA group (p=0.16). The OS rates at 52 weeks were 97% in the TAC group and 93% in the CsA group (p=0.50). The %FVC at 52 weeks in the per protocol populations significantly increased in both groups. None of the patients discontinued the treatment due to AEs.\nConclusions\nPSL plus TAC treatment was more likely to be associated with a higher short-term PFS rate compared with PSL plus CsA treatment. Further studies must be conducted to evaluate the longterm efficacy and safety of such treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons","subitem_publisher_language":"en"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"33179395","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/resp.13978","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: \"Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis/dermatomyositis-associated ILD: A randomized, open-label trial\", Volime 26, Issue 4, pp.370-377, 2021, which has been published in final form at  https://doi.org/10.1111/resp.13978. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1323-7799","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1440-1843","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11097269","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kamiya, Yosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kaida, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Akamatsu, Taisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kusagaya, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Satake, Yasuomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mori, Kazutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mikamo, Masashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuda, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yokomura, Koshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Koshimizu, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Toyoshima, Mikio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Imokawa, Shiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yasui, Hideki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Karayama, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Yutaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Inui, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-14"}],"displaytype":"detail","filename":"Respirology-26-370.pdf","filesize":[{"value":"572 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000079/files/Respirology-26-370.pdf"},"version_id":"9cb6f232-baa9-4b91-8110-d73ce1d8a4ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dermatomyositis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polymyositis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interstitial lung disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tacrolimus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclosporin A","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Treatment with prednisolone and tacrolimus versus prednisolone and cyclosporin A for polymyositis/dermatomyositis-associated interstitial lung disease: a randomized, open-label trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Treatment with prednisolone and tacrolimus versus prednisolone and cyclosporin A for polymyositis/dermatomyositis-associated interstitial lung disease: a randomized, open-label trial","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-21"},"publish_date":"2024-02-21","publish_status":"0","recid":"2000079","relation_version_is_last":true,"title":["Treatment with prednisolone and tacrolimus versus prednisolone and cyclosporin A for polymyositis/dermatomyositis-associated interstitial lung disease: a randomized, open-label trial"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-02-27T00:30:59.770860+00:00"}