{"created":"2024-03-07T05:40:14.718907+00:00","id":2000093,"links":{},"metadata":{"_buckets":{"deposit":"aa570b52-c97a-4549-9d4c-ee9e98173d36"},"_deposit":{"created_by":4,"id":"2000093","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000093"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000093","sets":["1:75:1709274151436"]},"author_link":[],"control_number":"2000093","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"50","bibliographicPageStart":"46","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"浜松医科大学小児科学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hamamatsu Journal of Pediatrics","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"症例は日齢11の男児．胆汁性嘔吐，血便の精査を行ったところ腸管壊死が疑われ，緊急手術を施行した．広範囲の小腸切除により残存小腸は空腸50cm，回腸10cm（回盲弁あり）となり，短腸症候群を来した．長期にわたる中心静脈栄養と経腸栄養の不足により，徐々に直接ビリルビン，AST・ALTの上昇を認め，小腸機能不全関連肝障害と診断した．本疾患の治療には静注用ω3系脂肪酸製剤の投与が有効であることが報告されているが，その代表薬であるOmegaven®は我が国では承認されていない薬剤である．\n本症例では経口にてω3系油脂高含有製剤であるEPA1100の投与を行い，肝機能障害の改善を認めた．それに加え不足していた脂肪酸もEPA1100の摂取により上昇した．ω3系脂肪酸の経口投与により短腸症候群の児の肝機能が改善するだけでなく，栄養状態の改善にも効果がある可能性が示唆された．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Intestinal failure-associated liver dysfunction (IFALD) is seen in patient with short bowel syndrome (SBS), and often become cause of death. Fish oil containing lipid emulsions such as Omegaven® is used to treat IFALD and good prognosis is reported in past studies. But in our country, Omegaven® is an unapproved drug and requires ethics committee approve for use. Here, we report a case of male neonate who underwent on resection of small intestine at 11th day of life because of small intestine necrosis. His small intestine was only 60 cm long after surgery, resulting in SBS. He developed IFALD at day 32. Blood checkup showed increases in direct bilirubin, AST, and ALT. Since we cannot use Omegaven® in our hospital, EPA1100, omega-3 fatty acid containing supplement, was administered orally to this patient. Liver dysfunction improved in two months after EPA1100 administration. In addition, blood concentration of eicosapentaenoic acid and docosahexaenoic acid increased, and arachidonic acid, fatty acid causing inflammation, decreased by fatty acid examination. There was no adverse effect seen in this patient. Oral administration of ω3 fatty acid containing supplement may improve liver function in patient with short bowel syndrome, and may be an alternative drug to intravenous fish oil emulsions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"浜松医科大学小児科学雑誌編集部","subitem_publisher_language":"ja"}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2024288596","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-2433","subitem_source_identifier_type":"EISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"馬場, 徹","creatorNameLang":"ja"},{"creatorName":"BABA, Toru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"竹林, 寛史","creatorNameLang":"ja"},{"creatorName":"TAKEBAYASHI, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近藤, 実由樹","creatorNameLang":"ja"},{"creatorName":"KONDO, Miyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-15"}],"displaytype":"detail","filename":"hjop_4_1_46.pdf","filesize":[{"value":"820 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000093/files/hjop_4_1_46.pdf"},"version_id":"eb168bc1-b735-4be8-a575-a9cb9f5cb767"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"小腸機能不全関連肝障害","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ω3系脂肪酸製剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"経口投与","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"小腸機能不全関連肝障害に対してω3系脂肪酸の経口投与が有効であった正期産児の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小腸機能不全関連肝障害に対してω3系脂肪酸の経口投与が有効であった正期産児の1例","subitem_title_language":"ja"},{"subitem_title":"An effectiveness of oral ω3 fatty acid containing supplement for intestinal failure-associated liver disease in term neonate","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["1709274151436"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-15"},"publish_date":"2024-03-15","publish_status":"0","recid":"2000093","relation_version_is_last":true,"title":["小腸機能不全関連肝障害に対してω3系脂肪酸の経口投与が有効であった正期産児の1例"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-03-05T07:58:29.273921+00:00"}