{"created":"2024-04-22T00:40:29.531881+00:00","id":2000193,"links":{},"metadata":{"_buckets":{"deposit":"c6a2d3c7-29cc-4193-bb67-0ff270ab376e"},"_deposit":{"created_by":4,"id":"2000193","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000193"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000193","sets":["1:11"]},"author_link":[],"control_number":"2000193","item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Influence of alternate-day dosing of vonoprazan","subitem_alternative_title_language":"en"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"963","bibliographicPageStart":"955","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"European Journal of Clinical Pharmacology","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載タイトル：Influence of daily versus alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Vonoprazan, a potassium-competitive acid blocker, inhibits gastric acid secretion and attenuates the antiplatelet function of clopidogrel more potently than esomeprazole. We investigated whether alternate-day dosing of vonoprazan might avoid this interaction with clopidogrel while providing sufficient gastric acid inhibition.\nMethods: Following 24 h of pH monitoring (control regimen), 12 healthy volunteers received three regimens (clopidogrel-only regimen: clopidogrel 75mg daily (q.d.); vonoprazan alternate-day regimen: vonoprazan 10mg every other day (q.o.d.) + clopidogrel 75mg q.d.; vonoprazan daily regimen: vonoprazan 10mg q.d. + clopidogrel 75mg q.d. for 14 days in a randomized open-label crossover manner. Intragastric pH monitoring was performed for 24 hours on day 13 in the clopidogrel-only regimen and vonoprazan q.d. regimens and for 48 hours on days 13 and 14 in the vonoprazan q.o.d. regimen. Serum gastrin and inhibition of platelet aggregation (IPA) were measured before the commencement of pH monitoring in each regimen.\nResults: Twelve volunteers completed the study. Equivalent median IPA values in the q.o.d. and q.d. regimens were measured (21.8% and 25%, respectively) and were significantly lower than that of the clopidogrel-only regimen (40.8%). Median pH4 holding time ratio on the vonoprazan q.o.d. regimen (49.7%) was superior to that of the clopidogrel-only regimen (18.4%), but was significantly inferior to that of the vonoprazan q.d. regimen (77.0%) (p<0.01).\nConclusion: Alternate-day administration of vonoprazan could not prevent the interaction between vonoprazan and clopidogrel and acid inhibition was inferior to vonoprazan daily administration, and appears to be of questionable clinical utility.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"35445847","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00228-022-03313-2","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00228-022-03313-2","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6970","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1432-1041","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00639585","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Higuchi, Tomohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamade, Mihoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Satoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tamura, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tani, Shinya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kagami, Takuma","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Uotani, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamaya, Yasushi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iwaizumi, Moriya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Osawa, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sugimoto, Ken","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Furuta, Takahisa","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-22"}],"displaytype":"detail","filename":"EJCP-78-955.pdf","filesize":[{"value":"664 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000193/files/EJCP-78-955.pdf"},"version_id":"bdf94b28-988f-4e39-89d3-c9af891d751b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vonoprazan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alternate-day dosing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"clopidogrel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ADP-induced platelet aggregation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastrin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pH4 holding time ratio","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Influence of daily vs. alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Influence of daily vs. alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-17"},"publish_date":"2024-05-17","publish_status":"0","recid":"2000193","relation_version_is_last":true,"title":["Influence of daily vs. alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-05-17T01:48:09.152945+00:00"}