{"created":"2025-02-13T06:29:57.846643+00:00","id":2000335,"links":{},"metadata":{"_buckets":{"deposit":"42ad23e3-350b-4e6b-aec9-a39bd203d5ae"},"_deposit":{"created_by":4,"id":"2000335","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000335"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000335","sets":["1:11"]},"author_link":[],"control_number":"2000335","item_3_biblio_info_5":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"22","bibliographicPageStart":"13","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Journal of Anesthesia","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Postoperative delirium is one of the most common complications after cardiovascular surgery in older adults. Benzodiazepines are a reported risk factor for delirium; however, there are no studies investigating remimazolam, a novel anesthetic agent. Therefore, we prospectively investigated the effect of remimazolam on postoperative delirium.\nMethods: We included elective cardiovascular surgery patients aged ≥ 65 years at Hamamatsu University Hospital between August 2020 and February 2022. Patients who received general anesthesia with remimazolam were compared with those who received other anesthetics (control group). The primary outcome was delirium within 5 days after surgery. Secondary outcomes were delirium during intensive care unit stay and hospitalization, total duration of delirium, subsyndromal delirium, and differences in the Mini-Mental State Examination scores from preoperative to postoperative days 2 and 5. To adjust for differences in the groups’ baseline covariates, we used stabilized inverse probability weighting as the primary analysis and propensity score matching as the sensitivity analysis.\nResults: We enrolled 200 patients; 78 in the remimazolam group and 122 in the control group. After stabilized inverse probability weighting, 30.3% of the remimazolam group patients and 26.6% of the control group patients developed delirium within 5 days (risk difference, 3.8%; 95% confidence interval, −11.5% to 19.1%; p=0.63). The secondary outcomes did not differ significantly between the groups, and the sensitivity analysis results were similar to those for the primary analysis.\nConclusion: Remimazolam was not significantly associated with postoperative delirium compared with other anesthetic agents.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"日本麻酔科学会 = Japanese Society of Anesthesiologists","subitem_publisher_language":"ja"}]},"item_3_relation_26":{"attribute_name":"item_3_relation_26","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"36220948","subitem_relation_type_select":"PMID"}}]},"item_3_relation_27":{"attribute_name":"item_3_relation_27","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"2024046927","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_relation_28":{"attribute_name":"item_3_relation_28","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00540-022-03119-7","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00540-022-03119-7","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0913-8668","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1438-8359","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"item_3_source_id_23","attribute_value_mlt":[{"subitem_source_identifier":"AA10852931","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aoki, Yoshitaka","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Kurita, Tadayoshi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Nakajima, Mikio","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Imai, Ryo","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuji","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Makino, Hiroshi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Kinoshita, Hiroyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Doi, Matsuyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Nakajima, Yoshiki","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-02-13"}],"displaytype":"detail","filename":"JA-37-13.pdf","filesize":[{"value":"991 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000335/files/JA-37-13.pdf"},"version_id":"30372721-81b7-4fc6-9c05-1a9692460940"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cardiovascular surgical procedures","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cognitive dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Post-intensive care unit delirium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mental status and dementia tests","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Remimazolam sedation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-26"},"publish_date":"2025-02-26","publish_status":"0","recid":"2000335","relation_version_is_last":true,"title":["Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-02-26T05:47:58.199380+00:00"}