{"created":"2025-02-14T06:41:51.992485+00:00","id":2000341,"links":{},"metadata":{"_buckets":{"deposit":"1ee21e02-6f90-4c2a-862d-cb373cd8f3c9"},"_deposit":{"created_by":4,"id":"2000341","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000341"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000341","sets":["1:11"]},"author_link":[],"control_number":"2000341","item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Risk factors of HCC after DAA therapy","subitem_alternative_title_language":"en"}]},"item_3_biblio_info_5":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-01-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"53","bibliographicPageStart":"43","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Hepatology Research","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: To determine risk factors associated with hepatocellular carcinoma (HCC) development following direct-acting antiviral (DAA) therapy.\nMethods: We enrolled patients with chronic hepatitis C who underwent DAA therapy and achieved sustained virologic response at 12 weeks between 2012 and 2018. Subsequently, patients were followed up. The primary endpoint was the development of HCC or the date of the last follow-up when the absence of HCC was confirmed. Uni- and multi-variate Cox proportional hazard models were used to identify factors contributing to HCC development, including gadoxetic acid-enhanced magnetic resonance imaging findings. The cumulative incidence rates of HCC development were calculated using the Kaplan–Meier method and differences between groups were assessed using the log-rank test.\nResults: The final study cohort comprised 482 patients (median age, 70.5 years; 242 men). The median follow-up period was 36.8 months. Among 482 patients, 96 developed HCC (19.9%). The 1-, 3-, and 5-year cumulative rates of HCC development were 4.9%, 18.6%, and 30.5%, respectively. Multivariate analysis revealed that age, male sex, history of HCC, and hepatobiliary phase (HBP) hypointense nodules without arterial phase hyperenhancement (APHE) were independent risk factors significantly associated with HCC development (P<0.001–0.04). The highest risk group included patients with both a history of HCC and the presence of HBP hypointense nodules without APHE (the 1- and 3-year cumulative HCC development rates were 14.2% and 62.2%, respectively).\nConclusion: History of HCC and presence of HBP hypointense nodules without APHE were strong risk factors for HCC development following DAA therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons","subitem_publisher_language":"en"},{"subitem_publisher":"日本肝臓学会 = The Japan Society of Hepatology","subitem_publisher_language":"ja"}]},"item_3_relation_26":{"attribute_name":"item_3_relation_26","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"37676063","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"item_3_relation_28","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/hepr.13964","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: \"Magnetic resonance imaging-based risk factors of hepatocellular carcinoma after direct-acting antiviral therapy: A multicenter observational study\", 54(1), pp43-53, 2024, which has been published in final form at  https://doi.org/10.1111/hepr.13964. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1386-6346","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1872-034X","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"item_3_source_id_23","attribute_value_mlt":[{"subitem_source_identifier":"AA11140867","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichikawa, Shintaro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Motosugi, Utaroh","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Sawai, Yoshiyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Ishida, Hisashi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Imai, Yasuharu","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Kozaka, Kazuto","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Tsurusaki, Masakatsu","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Sofue, Keitaro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Murakami, Takamichi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Kawai, Nobuyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Matsuo, Masayuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Fukukura, Yoshihiko","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Mawatari, Seiichi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Shimizu, Tatsuya","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Morisaka, Hiroyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Inoue, Taisuke","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Goshima, Satoshi","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-02-14"}],"displaytype":"detail","filename":"Hepatol Res-54-43.pdf","filesize":[{"value":"10.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000341/files/Hepatol Res-54-43.pdf"},"version_id":"6d4f47da-9bf6-47e7-9a7e-8c097c281f08"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"liver","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatitis C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"magnetic resonance imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"risk factors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"arterial phase hyperenhancement","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"direct-acting antiviral therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatobiliary phase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Magnetic resonance imaging-based risk factors of hepatocellular carcinoma after direct-acting antiviral therapy: A multicenter observational study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Magnetic resonance imaging-based risk factors of hepatocellular carcinoma after direct-acting antiviral therapy: A multicenter observational study","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-26"},"publish_date":"2025-02-26","publish_status":"0","recid":"2000341","relation_version_is_last":true,"title":["Magnetic resonance imaging-based risk factors of hepatocellular carcinoma after direct-acting antiviral therapy: A multicenter observational study"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-02-26T06:29:14.379915+00:00"}