{"created":"2025-03-03T04:58:53.897153+00:00","id":2000353,"links":{},"metadata":{"_buckets":{"deposit":"0e657ab7-53d2-4b1e-a251-3febdf1cee31"},"_deposit":{"created_by":4,"id":"2000353","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000353"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000353","sets":["1:75:1740964477960"]},"author_link":[],"control_number":"2000353","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"18","bibliographicPageStart":"12","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"浜松医科大学小児科学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hamamatsu Journal of Pediatrics","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"食物蛋白誘発胃腸炎（food protein induced enterocolitis syndrome：FPIES）は，現時点でメカニズム不明の疾患である．その診断は，被疑食品を摂取して概ね1–4 時間後に消化器症状が誘発されることを繰り返すことでなされる．ただし，2回の症状誘発の既往がある児に食物経口負荷試験（oral food challenge：OFC）を行うと，約半数は陰性となる．また，発症前に無症状摂取歴が無い場合もOFCが陰性となる可能性が高い．そのため，これらをふまえて積極的に診断目的のOFCを行い，不要な除去をしないことが肝要である．また，発症から半年など早期に寛解しやすいという一般的認識に対しては，確定診断をもとにした真の予後調査を行い，評価されるべき内容と考えられる．真のFPIESの予後を明らかにし，適切な寛解確認目的のOFC間隔を決定していくことや経口免疫療法の有効性などが，今後の検討課題である．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Food Protein-Induced Enterocolitis Syndrome (FPIES) is a disorder with an unknown mechanism at present. Diagnosis is made by repeatedly inducing gastrointestinal symptoms approximately 1–4 hours after ingestion of the culprit food. However, when an oral food challenge (OFC) is conducted on children with a history of two symptom inductions, about half test negative, indicating they may not have FPIES. Additionally, if there is no history of asymptomatic ingestion before onset, it is also likely not FPIES. Therefore, it is crucial to actively perform diagnostic OFCs to avoid unnecessary elimination. Furthermore, true prognosis studies based on confirmed diagnoses should evaluate whether early remission, such as within six months from onset, is common. Clarifying the true prognosis of FPIES, determining appropriate intervals for remission confirmation OFCs, and assessing the feasibility and effectiveness of oral immunotherapy are future research topics.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"浜松医科大学小児科学雑誌編集部","subitem_publisher_language":"ja"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-2433","subitem_source_identifier_type":"EISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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