{"created":"2025-03-04T00:54:18.093461+00:00","id":2000360,"links":{},"metadata":{"_buckets":{"deposit":"78b2d101-99f2-4023-b6a7-84fd71697ade"},"_deposit":{"created_by":4,"id":"2000360","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000360"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000360","sets":["1:75:1740964477960"]},"author_link":[],"control_number":"2000360","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"59","bibliographicPageStart":"52","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"浜松医科大学小児科学雑誌","bibliographic_titleLang":"ja"},{"bibliographic_title":"Hamamatsu Journal of Pediatrics","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"梅毒合併妊婦に対して，妊娠中に無治療であると子宮内胎児死亡，死産，新生児死亡，早産のリスクが高まる．無治療妊婦から出生した児の約15%に先天梅毒の症状・所見を呈することが報告されているが，その多彩な合併症や神経発達予後に関する報告は少ない．症例は在胎33週4日，出生体重1,584g の女児．出生後に敗血症所見を呈するとともに新生児遷延性肺高血圧症を合併して，抗菌薬投与と一酸化窒素吸入療法を含めた集中管理を要した．妊娠中無治療母体からの出生，身体所見，骨X線所見，梅毒血清反応所見から先天梅毒と診断し，ベンジルペニシリンカリウム 5万単位/kg/日を計10日間投与した．頭部MRIや自動聴性脳幹反応検査では異常所見を認めず，修正3歳までの発達検査では明らかな発達遅延はなかったが，暦5歳の知能検査ではIQ78であり軽度知的障害が示唆された．本論文では，本症例における急性期合併症と神経発達予後について，先天梅毒との関連を文献的考察を加えて報告する．","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Untreated maternal syphilis during pregnancy increases the risk of intrauterine fetal death, stillbirth, neonatal death, and preterm birth. Approximately 15% of infants born to untreated pregnant women develop symptoms or findings of congenital syphilis; however, there are few reports on its diverse complications and long-term neurodevelopmental outcomes. The patient was a female infant born at 33 weeks and 4 days of gestation, with a birth weight of 1,584 g. The infant developed signs of sepsis and persistent pulmonary hypertension of the newborn, requiring intensive care, including antibiotic therapy and inhaled nitric oxide treatment. Born to an untreated mother, the infant was diagnosed with congenital syphilis based on physical and radiological findings and serological tests and was treated with benzylpenicillin potassium at 50,000 units/kg/day for 10 days. Brain MRI and automated auditory brainstem response testing showed no abnormalities. While developmental assessments up to the corrected age of three years revealed no significant delays, an intelligence test at five years of chronological age indicated a mild intellectual disability with an IQ of 78.\nThis report discusses the acute-phase complications and neurodevelopmental outcomes of this case in relation to congenital syphilis, with a review of the relevant literature.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"浜松医科大学小児科学雑誌編集部","subitem_publisher_language":"ja"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-2433","subitem_source_identifier_type":"EISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000403781551","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000403781551"},{"affiliationNameIdentifier":"05x23rx38","affiliationNameIdentifierScheme":"ROR","affiliationNameIdentifierURI":"https://ror.org/05x23rx38"}],"affiliationNames":[{"affiliationName":"静岡県立こども病院","affiliationNameLang":"ja"},{"affiliationName":"シズオカケンリツコドモビョウイン","affiliationNameLang":"ja-Kana"},{"affiliationName":"Shizuoka Children's Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"浅井, 佑哉","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"アサイ, ユウヤ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"},{"creatorName":"ASAI, Yuya","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"児玉, 洋平","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"コダマ, ヨウヘイ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"},{"creatorName":"KODAMA, Yohei","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"浅沼, 賀洋","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"アサヌマ, ノリヒロ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"},{"creatorName":"ASANUMA, Norihiro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"中野, 玲二","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"ナカノ, レイジ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"},{"creatorName":"NAKANO, Reiji","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-15"}],"displaytype":"detail","filename":"hjop_5_1_52.pdf","filesize":[{"value":"1007 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000360/files/hjop_5_1_52.pdf"},"version_id":"3dc78a08-90bd-4746-9789-b93da742377e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"先天梅毒","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"早産児","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"新生児遷延性肺高血圧症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"神経発達","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"妊娠中無治療であった梅毒合併妊婦から出生した先天梅毒の早産児例：急性期合併症と長期神経発達予後の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"妊娠中無治療であった梅毒合併妊婦から出生した先天梅毒の早産児例：急性期合併症と長期神経発達予後の検討","subitem_title_language":"ja"},{"subitem_title":"A preterm infant with congenital syphilis born to a mother who was untreated during pregnancy: acute-phase complications and long-term neurodevelopmental outcomes","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["1740964477960"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-15"},"publish_date":"2025-03-15","publish_status":"0","recid":"2000360","relation_version_is_last":true,"title":["妊娠中無治療であった梅毒合併妊婦から出生した先天梅毒の早産児例：急性期合併症と長期神経発達予後の検討"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-03-14T05:03:40.642125+00:00"}