{"created":"2025-03-17T05:05:35.171490+00:00","id":2000364,"links":{},"metadata":{"_buckets":{"deposit":"d0577691-dc82-4371-8f5d-f94af71908a9"},"_deposit":{"created_by":4,"id":"2000364","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000364"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000364","sets":["1:11","1:1741755518511"]},"author_link":[],"control_number":"2000364","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"2201634","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"European Respiratory Journal","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"令和6年度 浜松医科大学優秀論文賞：最優秀論文賞\n受賞者：柄山　正人","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nAcute exacerbation of idiopathic interstitial pneumonias (AE-IIPs) induces permanent pulmonary dysfunction and is potentially lethal. The unpredictable occurrence of AE-IIPs remains an important clinical issue in the management of IIPs.\nMethods\nIn this multicentre, retrospective, observational study, a predictive score for AE-IIPs was designed using clinical factors based on multivariate Fine–Gray analysis in patients with IIPs.\nResults\nBased on multivariate Fine–Gray analysis in an exploratory cohort of 487 patients with IIPs, the predictive score for AE-IIPs was determined as follows: 1 point each was added for honeycombing on high-resolution computed tomography (H), age >75 years (A) and lactate dehydrogenase level >222 U·L−1 (L); the total score ranged from 0 to 3 (HAL score). The HAL score discriminated the risk of AE-IIPs with a C-index of 0.62 (95% CI 0.56–0.67); this discrimination was verified in a validation cohort of 402 patients with IIPs with a C-index of 0.67 (95% CI 0.60–0.73). In a combined cohort, the estimated\ncumulative risks for AE-IIPs at 1, 2, 3, 5 and 10 years were 1.9%, 3.5%, 5.1%, 7.7% and 12.9%, respectively, in the total score 0 group; 4.7%, 8.3%, 12.0%, 17.7% and 28.4%, respectively, in the total score 1 group; and 8.0%, 14.2%, 19.7%, 28.7% and 43.0%, respectively, in the total score ⩾2 group. Subgroup analysis revealed that the HAL score was applicable to patients with and without idiopathic pulmonary fibrosis.\nConclusions\nThe HAL score discriminated the risk of AE-IIPs and could aid in the management of IIPs.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"European Respiratory Society","subitem_publisher_language":"en"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"36822633","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1183/13993003.01634-2022","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0903-1936","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1399-3003","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA10688995","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000089376696","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000089376696"}],"affiliationNames":[{"affiliationName":"浜松医科大学","affiliationNameLang":"ja"},{"affiliationName":"ハママツイカダイガク","affiliationNameLang":"ja-Kana"},{"affiliationName":"Hamamatsu University School of Medicine","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Karayama, Masato","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Aoshima, Yoichiro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suzuki, Takahito","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000417723416","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000417723416"}],"affiliationNames":[{"affiliationName":"静岡市立清水病院","affiliationNameLang":"ja"},{"affiliationName":"シズオカシリツシミズビョウイン","affiliationNameLang":"ja-Kana"},{"affiliationName":"Shizuoka City Shimizu Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Mori, Kazutaka","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Yoshizawa, Nobuko","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Ichikawa, Shintaro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000417648727","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000417648727"}],"affiliationNames":[{"affiliationName":"聖隷三方原病院","affiliationNameLang":"ja"},{"affiliationName":"セイレイミカタハラビョウイン","affiliationNameLang":"ja-Kana"},{"affiliationName":"Seirei Mikatahara General Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kato, Shinpei","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Yokomura, Koshi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000403778408","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000403778408"}],"affiliationNames":[{"affiliationName":"聖隷浜松病院","affiliationNameLang":"ja"},{"affiliationName":"セイレイハママツビョウイン","affiliationNameLang":"ja-Kana"},{"affiliationName":"Seirei Hamamatsu General Hospital","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Kono, Masato","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Hashimoto, Dai","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Inoue, Yusuke","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Yasui, Hideki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Goshima, Satoshi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Inui, Naoki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-08"}],"displaytype":"detail","filename":"最優秀_ERJ-61-2201634.pdf","filesize":[{"value":"890 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"label":"ERJ-61-2201634.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000364/files/最優秀_ERJ-61-2201634.pdf"},"version_id":"e09258c7-3503-48f0-a787-901d437dc858"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A predictive model for acute exacerbation of idiopathic interstitial pneumonias","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A predictive model for acute exacerbation of idiopathic interstitial pneumonias","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11","1741755518511"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-04-15"},"publish_date":"2025-04-15","publish_status":"0","recid":"2000364","relation_version_is_last":true,"title":["A predictive model for acute exacerbation of idiopathic interstitial pneumonias"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-04-22T00:22:51.768326+00:00"}