{"created":"2025-04-08T02:13:49.407072+00:00","id":2000383,"links":{},"metadata":{"_buckets":{"deposit":"7be0e4fe-4244-4c07-b8da-faf81e2c8c73"},"_deposit":{"created_by":4,"id":"2000383","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000383"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000383","sets":["1:11","1:1741755518511"]},"author_link":[],"control_number":"2000383","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-06-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"23","bibliographicPageEnd":"2789","bibliographicPageStart":"2780","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Oncology","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"令和6年 浜松医科大学優秀論文賞：最優秀論文賞\n受賞者：乾　直輝","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE\nWe evaluated the efficacy and safety of antiemetic therapy with olanzapine, a neurokinin-1 receptor antagonist (RA), a 5-hydroxytryptamine-3 (5-HT3) RA, and dexamethasone for preventing chemotherapy-induced nausea and vomiting in patients receiving carboplatin-containing chemotherapy.\nPATIENTS AND METHODS\nChemotherapy-naïve patients scheduled to receive carboplatin (AUC ≥5) were randomly assigned to receive either olanzapine 5 mg once daily (olanzapine group) or placebo (placebo group) in combination with aprepitant, a 5-HT3 RA, and dexamethasone. The primary end point was the complete response (CR; no vomiting and no rescue therapy) rate in the overall phase (0-120 hours). Secondary end points included the proportion of patients free of nausea and safety.\nRESULTS\nIn total, 355 patients (78.6% male, median age 72 years, 100% thoracic cancer), including 175 and 180 patients in the olanzapine and placebo groups, respectively, were evaluated. The overall CR rate was 86.9% in the olanzapine group versus 80.6% in the placebo group. The intergroup difference in the overall CR rate was 6.3% (95% CI, ―1.3 to 13.9). The proportions of patients free of chemotherapyinduced nausea in the overall (88.6% in the olanzapine group v 75.0% in the placebo group) and delayed (89.7% v 75.6%, respectively) phases were significantly higher in the olanzapine group than in the placebo group (both P< .001). Somnolence was observed in 43 (24.6%) and 41 (22.9%) patients in the olanzapine and placebo groups, respectively, and no events were grade ≥3 in severity.\nCONCLUSION\nThe addition of olanzapine was not associated with a significant increase in the overall CR rate. Regarding the prevention of nausea, adding olanzapine provided better control in patients receiving carboplatin-containing chemotherapy, which needs further exploration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wolters Kluwer Health","subitem_publisher_language":"en"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"38833659","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1200/JCO.24.00278","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2024 by American Society of Clinical Oncology. Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0732-183X","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1527-7755","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA10638385","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000089376696","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000089376696"}],"affiliationNames":[{"affiliationName":"浜松医科大学　他","affiliationNameLang":"ja"},{"affiliationName":"ハママツイカダイガク　ホカ","affiliationNameLang":"ja-Kana"},{"affiliationName":"Hamamatsu University School of Medicine..et al.","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Inui, Naoki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suzuki, Takahito","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Tanaka, Kazuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Karayama, Masato","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Inoue, Yusuke","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI"}]}],"creatorNames":[{"creatorName":"Mori, Kazutaka","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Yasui, Hideki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Matsuura, Shun","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Nishimoto, Koji","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Matsui, Takashi","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Asada, Kazuhiro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Hashimoto, Dai","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Fujii, Masato","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Niwa, Mitsuru","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Uehara, Masahiro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Matsuda, Hiroyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Koda, Keigo","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Ikeda, Masaki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Inami, Nao","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Tamiya, Yutaro","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Kato, Masato","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Nakano, Hideki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Mino, Yasuaki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki","creatorNameLang":"en","creatorNameType":"Personal"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-08"}],"displaytype":"detail","filename":"最優秀_JCO-42-2780.pdf","filesize":[{"value":"977 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"JCO-42-2780.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000383/files/最優秀_JCO-42-2780.pdf"},"version_id":"86cc40e3-2e3b-4b90-bcf8-497d87a1f1af"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced  Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced  Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11","1741755518511"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-04-15"},"publish_date":"2025-04-15","publish_status":"0","recid":"2000383","relation_version_is_last":true,"title":["Olanzapine Plus Triple Antiemetic Therapy for the Prevention of Carboplatin-Induced  Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-04-22T00:27:06.003700+00:00"}