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FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation
http://hdl.handle.net/10271/0002000462
http://hdl.handle.net/10271/0002000462c75687ed-36df-4ca3-9905-b451173898b0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (2.1 MB)
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| Item type | 共通アイテムタイプ / Common item types(1) | |||||||||||
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| 公開日 | 2025-08-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | FGF21 upregulation by hepatitis C virus via the eIF2α-ATF4 pathway: implications for interferon signaling suppression and TRIM31-mediated TSC degradation | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | hepatitis C virus | |||||||||||
| キーワード | ||||||||||||
| 主題 | FGF21 | |||||||||||
| キーワード | ||||||||||||
| 主題 | ATF4 | |||||||||||
| キーワード | ||||||||||||
| 主題 | CREBH | |||||||||||
| キーワード | ||||||||||||
| 主題 | TRIM31 | |||||||||||
| キーワード | ||||||||||||
| 主題 | SOCS2 | |||||||||||
| キーワード | ||||||||||||
| 主題 | ER stress | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | C型肝炎ウイルス感染によりeIF2α-ATF4シグナル伝達経路を介して誘導されるFGF21のアップレギュレーション：インターフェロンシグナル伝達の抑制およびTRIM31依存的なTSCの分解への影響 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
Liu, Liang
× Liu, Liang
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| 著者情報 |
リウ, リャン
× リウ, リャン
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| 書誌情報 |
en : Frontiers in Microbiology 巻 15, p. 1456108, ページ数 19, 発行日 2024-08-15 |
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| 出版者 | ||||||||||||
| 出版者 | Frontiers Media | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright 2024 Liu, Ito, Sakai, Liu, Ohta, Saito, Nakashima, Satoh, Konno and Suzuki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Hepatitis C virus (HCV) infection is a major cause of chronic liver diseases and is known to induce endoplasmic reticulum (ER) stress, which alters cellular homeostasis and metabolic processes. While ER stress is implicated in HCV-related diseases, its precise role remains unclear. This study identifies fibroblast growth factor 21 (FGF21) as a key host factor significantly upregulated by HCV infection. Mechanistic analyses reveal that the activation of the FGF21 promoter by HCV is primarily mediated by the transcription factor ATF4, which is upregulated through the phosphorylation of eIF2αinduced by ER stress. Additionally, CREBH activation further enhances ATF4 expression, contributing to increased FGF21 levels. TRIB3, upregulated by ATF4, acts as a negative regulator of FGF21 expression. The study also identifies FGF21-dependent upregulation of SOCS2 and TRIM31 in HCV-infected cells. SOCS2 contributes to the suppression of type 1 interferon signaling, aiding viral persistence, while TRIM31 promotes the degradation of the tumor suppressor protein TSC, activating the mTORC1 pathway and potentially promoting liver cell proliferation. These findings suggest that FGF21 upregulation in HCV-infected cells may play a role in both immune response regulation and cell proliferation, contributing to sustained viral infection and disease progression. | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 13802 | |||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与機関名 | Hamamatsu University School of Medicine | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-09-20 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第991号 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子 | 1664-302X | |||||||||||
| PubMed番号 (PMID) | ||||||||||||
| 関連識別子 | 39211324 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.3389/fmicb.2024.1456108 | |||||||||||
| 学位論文要旨/本文へのリンク | ||||||||||||
| 関連識別子 | http://hdl.handle.net/10271/0002000244 | |||||||||||
| 関連名称 | 学位論文要旨 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
