WEKO3
アイテム
Evaluation of brain activation related to resting pain using functional magnetic resonance imaging in cynomolgus macaques undergoing knee surgery
http://hdl.handle.net/10271/0002000463
http://hdl.handle.net/10271/000200046302ab9152-d1cc-4d07-bc15-364628463609
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (860 KB)
|
.png)
|
| Item type | 共通アイテムタイプ / Common item types(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-08-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Evaluation of brain activation related to resting pain using functional magnetic resonance imaging in cynomolgus macaques undergoing knee surgery | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | cingulate cortex | |||||||||||
| キーワード | ||||||||||||
| 主題 | fMRI | |||||||||||
| キーワード | ||||||||||||
| 主題 | insular cortex | |||||||||||
| キーワード | ||||||||||||
| 主題 | knee surgery | |||||||||||
| キーワード | ||||||||||||
| 主題 | macaques | |||||||||||
| キーワード | ||||||||||||
| 主題 | resting pain | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | 膝関節手術を受けたカニクイザルにおける安静時疼痛に関連する脳活動の機能的磁気共鳴画像法による評価 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
一ノ瀨, 初美
× 一ノ瀨, 初美
|
|||||||||||
| 書誌情報 |
en : Journal of Orthopaedics 巻 52, p. 12-16, 発行日 2024-06 |
|||||||||||
| 出版者 | ||||||||||||
| 出版者 | Elsevier | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright 2024 This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Purpose: Functional magnetic resonance imaging (fMRI) visualizes hemodynamic responses associated with brain and spinal cord activation. Various types of pain have been objectively assessed using fMRI as considerable brain activations. This study aimed to develop a pain model in cynomolgus macaques undergoing knee surgery and confirm brain activation due to resting pain after knee surgery. Methods: An osteochondral graft surgery on the femoral condyle in the unilateral knee was performed on four cynomolgus macaques (Macaca fascicularis). Resting pain was evaluated as changes in brain fMRI findings with a 3.0-T MRI scanner preoperatively, postoperatively, and after postoperative administration of morphine. In the fMRI analysis, Z-values >1.96 were considered statistically significant. Results: Brain activation without stimulation after surgery in the cingulate cortex (3.09) and insular cortex (3.06) on the opposite side of the surgery was significantly greater than that before surgery (1.05 and 1.03, respectively) according to fMRI. After the administration of morphine, activation due to resting pain decreased in the cingulate cortex (1.38) and insular cortex (1.21). Conclusion: Osteochondral graft surgery on the femoral condyle can lead to postoperative resting pain. fMRI can reveal activation in pain-related brain areas and evaluate resting pain due to knee surgery. |
|||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与機関名 | Hamamatsu University School of Medicin | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-09-20 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第992号 | |||||||||||
| PISSN | ||||||||||||
| 収録物識別子 | 2589-9082 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子 | 0972-978X | |||||||||||
| PubMed番号 (PMID) | ||||||||||||
| 関連識別子 | 38404703 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.jor.2024.02.012 | |||||||||||
| 学位論文要旨/本文へのリンク | ||||||||||||
| 関連識別子 | http://hdl.handle.net/10271/0002000245 | |||||||||||
| 関連名称 | 学位論文要旨 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
