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Comparative analysis of gene expression profiles in the adipose tissue of obese adult mice with rapid infantile growth after undernourishment in utero
http://hdl.handle.net/10271/0002000466
http://hdl.handle.net/10271/0002000466dbae6352-5b49-4193-8e0c-547ea4593922
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (9.7 MB)
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| Item type | 共通アイテムタイプ / Common item types(1) | |||||||||||
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| 公開日 | 2025-08-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Comparative analysis of gene expression profiles in the adipose tissue of obese adult mice with rapid infantile growth after undernourishment in utero | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | obesity | |||||||||||
| キーワード | ||||||||||||
| 主題 | pregnancy | |||||||||||
| キーワード | ||||||||||||
| 主題 | adipose tissue | |||||||||||
| キーワード | ||||||||||||
| 主題 | inflammation | |||||||||||
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| 主題 | catch-up growth | |||||||||||
| キーワード | ||||||||||||
| 主題 | Developmental Origins of Health and Disease (DOHaD) | |||||||||||
| キーワード | ||||||||||||
| 主題 | low birth weight | |||||||||||
| キーワード | ||||||||||||
| 主題 | macrophage | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | 子宮内低栄養の後、授乳期の急速な成長を経験した肥満成獣マウスの脂肪組織における遺伝子発現プロファイルの比較解析 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
鈴木, 美沙子
× 鈴木, 美沙子
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| 書誌情報 |
en : Frontiers in Endocrinology 巻 13, p. 818064, ページ数 15, 発行日 2022-02-24 |
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| 出版者 | ||||||||||||
| 出版者 | Frontiers Media | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright 2022 Suzuki, Kohmura-Kobayashi, Ueda, Furuta-Isomura, Matsumoto, Oda, Kawai, Itoh, Matsuya, Narumi, Tamura, Uchida, Mochizuki and Itoh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Rapid infantile growth (RG) markedly increases the risk of obesity and metabolic disorders in adulthood, particularly among neonates born small. To elucidate the molecular mechanisms by which RG following undernourishment in utero (UN) contributes to the deterioration of adult fat deposition, we developed a UN mouse model using maternal energy restriction, followed by RG achieved by adjustments to 4 pups per litter soon after birth. A high-fat diet (HFD) was fed to weaned pups treated or not (Veh) with tauroursodeoxycholic acid (TU). UN-RG pups showed the deterioration of diet-induced obesity and fat deposition, which was ameliorated by TU. We performed a microarray analysis of epididymal adipose tissue and two gene enrichment analyses (NN-Veh vs UN-RD-Veh and UN-RG-Veh vs UN-RG-TU). The results obtained identified 4 common gene ontologies (GO) terms of inflammatory pathways. In addition to the inflammatory characteristics of 4 GO terms, the results of heatmap and principal component analyses of the representative genes from 4 GO terms, genes of interest (GOI; Saa3, Ubd, S100a8, Hpx, Casp1, Agt, Ptgs2) selected from the 4 GO terms, and immunohistochemistry of macrophages collectively suggested the critical involvement of inflammation in the regulation of fat deposition in the responses to UN and TU. Therefore, the present results support the ‘Developmental Origins of Metaflammation’, the last word of which was recently proposed by the concept of metabolic disorders induced by low-grade systemic inflammation. | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与機関名 | Hamamatsu University School of Medicine | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-09-20 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第996号 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子 | 1664-2392 | |||||||||||
| PubMed番号 (PMID) | ||||||||||||
| 関連識別子 | 35295992 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.3389/fendo.2022.818064 | |||||||||||
| 学位論文要旨/本文へのリンク | ||||||||||||
| 関連識別子 | http://hdl.handle.net/10271/0002000249 | |||||||||||
| 関連名称 | 学位論文要旨 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
