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Assessment of therapeutic effects of combined treatment with cisplatin and anti-mouse programmed death (PD)-1 antibody in a mouse urothelial cancer model
http://hdl.handle.net/10271/0002000469
http://hdl.handle.net/10271/00020004690e3d5560-c562-425f-8aab-f0458d23c13d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (2.3 MB)
Download is available from 2026/3/27.
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| Item type | 共通アイテムタイプ / Common item types(1) | |||||||||||
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| 公開日 | 2025-07-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Assessment of therapeutic effects of combined treatment with cisplatin and anti-mouse programmed death (PD)-1 antibody in a mouse urothelial cancer model | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | Urothelial carcinoma | |||||||||||
| キーワード | ||||||||||||
| 主題 | cisplatin | |||||||||||
| キーワード | ||||||||||||
| 主題 | anti-mouse PD-1 antibody immune checkpoint inhibitor | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | マウス尿路上皮がんモデルにおけるシスプラチンおよび抗マウスPD-1抗体併用療法の治療効果の評価 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | embargoed access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||
| 著者 |
佐藤, 亮
× 佐藤, 亮
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| 書誌情報 |
en : ANTICANCER RESEARCH 巻 44, 号 4, p. 1417-1423, 発行日 2024-03-27 |
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| 出版者 | ||||||||||||
| 出版者 | International Institute of Anticancer Research | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Background/Aim: The therapeutic impact of combination treatment with an immune checkpoint inhibitor (ICI) and chemotherapeutic agent on patients with urothelial cancer (UC) remains controversial. Therefore, the present study investigated differences in the therapeutic effects of combination therapy with cisplatin plus anti-mouse programmed death (PD)-1 antibody according to the dose of cisplatin using the mouse bladder tumor model MBT2. Materials and Methods: The effects of treatment with two different doses cisplatin and/or anti-mouse PD-1 antibody on tumor growth after the subcutaneous injection of MBT2 cells were compared. Infiltrating patterns of lymphocytes into tumors after treatment were assessed using immunohistochemical staining. Results: MBT2 tumor volumes were significantly larger in mice receiving high-dose cisplatin alone than in those receiving low-dose cisplatin alone. Combination treatment with cisplatin plus anti-mouse PD-1 antibody exerted significantly stronger growth inhibitory effects on MBT2 tumors than treatment with either agent alone, irrespective of cisplatin doses; however, no significant differences were observed in MBT2 tumor volumes between mice receiving anti-mouse PD-1 antibody plus high-dose cisplatin and those receiving anti-mouse PD-1 antibody plus low-dose cisplatin. Furthermore, CD8+ to CD3+ and CD8+ to CD11b+ T-lymphocyte ratios in MBT2 tumors were both significantly higher in the low-dose cisplatin alone group than in the high-dose cisplatin alone group, whereas no significant differences were noted in either ratio between the two different combination treatment regimens. Conclusion: When combined with ICI, a lower dose of cisplatin may achieve favorable antitumor effects in UC patients by preventing lymphocyte exhaustion. | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||||||
| 学位授与機関識別子 | 13802 | |||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与機関名 | Hamamatsu University School of Medicine | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2024-07-19 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第990号 | |||||||||||
| PISSN | ||||||||||||
| 収録物識別子 | 0250-7005 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子 | 1791-7530 | |||||||||||
| NII書誌ID (NCID) | ||||||||||||
| 収録物識別子 | AA10625860 | |||||||||||
| PubMed番号 (PMID) | ||||||||||||
| 関連識別子 | 38537988 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.21873/anticanres.16938 | |||||||||||
| 学位論文要旨/本文へのリンク | ||||||||||||
| 関連識別子 | http://hdl.handle.net/10271/0002000242 | |||||||||||
| 関連名称 | 学位論文要旨 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
