| アイテムタイプ |
共通アイテムタイプ_旧(1) |
| 公開日 |
2025-10-21 |
| タイトル |
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タイトル |
Prevention of Atopic Dermatitis in High-risk Neonates via Different Types of Moisturizer Application: a Randomized, Blinded, Parallel, Three-group, Phase II Trial (PAF study) |
| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
atopic dermatitis |
| キーワード |
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主題 |
Fam’s Baby |
| キーワード |
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主題 |
moisturizer |
| キーワード |
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|
主題 |
neonate |
| キーワード |
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主題 |
prevent |
| キーワード |
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主題 |
randomized controlled trial |
| その他のタイトル |
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その他のタイトル |
ハイリスク新生児を対象とした保湿剤の種類によるアトピー性皮膚炎予防効果を探索する評価者盲検無作為化三群並行群間比較試験 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Inuzuka, Y
Yamamoto-Hanada, K
Kobayashi, T
Pak, K
Toyokuni, K
Ogita, H
Miyoshi, T
Ogawa, K
Sago, H
Ohya, Y
|
| 著者情報 |
犬塚, 祐介
|
| 書誌情報 |
en : Journal of the European Academy of Dermatology and Venereology
巻 37,
号 12,
p. 2526-2536,
発行日 2023-11-27
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| 出版者 |
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出版者 |
John Wiley and Sons |
| 権利 |
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|
権利情報 |
This is the peer reviewed version of the following article: "Prevention of Atopic Dermatitis in High-risk Neonates via Different Types of Moisturizer Application: a Randomized, Blinded, Parallel, Three-group, Phase II Trial (PAF study)", 37(12), pp2526-2536, c2023, which has been published in final form at https://doi.org/10.1111/jdv.19375. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background
The effectiveness of moisturizers in preventing infant atopic dermatitis (AD) remains unclear. We previously showed that using 2e moisturizer of commercial moisturizer (Shiseido Japan Co., Ltd., Tokyo, Japan) at least once a day significantly prevented AD in infants as compared with as-needed petroleum jelly. This trial aimed to determine the effectiveness of twice- or once-daily application of Fam’s Baby moisturizer (Fam’s Inc., Tokyo, Japan) in preventing AD compared with once-daily 2e moisturizer.
Methods
This trial was a single-center, three-parallel-group, assessor-blinded, superiority, individually randomized, controlled, phase II trial that was conducted from August 25, 2020 to September 28, 2021. We randomly assigned 60 newborns with at least one parent or sibling who has AD to receive Fam’s Baby moisturizer twice daily (Group A) or once daily (Group B), or 2e once daily (Group C) in a 1:1:1 ratio until they were 32 weeks old. The primary outcome was the time to AD onset.
Results
AD was observed in 11/20 (55%), 5/20 (25%), and 10/20 (50%), infants in Groups A, B, and C, respectively. Cumulative incidence values for AD according to the Kaplan–Meier method showed that infants in Group B tended to maintain an intact skin for a longer period than those in Group C (median time, not reached [NR] vs. 212 days, log-rank test, p=0.064). Cox regression analysis showed that the risk of AD tended to be lower in Group B (hazard ratio with group C as control, 0.36; 95% confidential intervals: 0.12–1.06). No serious adverse events occurred in any of the enrolled infants.
Conclusion
Fam’s Baby moisturizer may better prevent AD than 2e. Further large-scale trials should be performed to confirm the efficacy of Fam’s Baby moisturizer in preventing AD in infants. |
| 注記 |
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内容記述 |
Figure 2~4は登録無し |
| 注記 |
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内容記述 |
乙第604号 学位論文の出版タイプが異なる版 |
| PISSN |
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収録物識別子 |
0926-9959 |
| EISSN |
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収録物識別子 |
1468-3083 |
| NII書誌ID (NCID) |
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収録物識別子 |
AA10848377 |
| PubMed番号 (PMID) |
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関連識別子 |
37478291 |
| 出版社DOI |
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関連識別子 |
https://doi.org/10.1111/jdv.19375 |
| 要旨⇔論文へのリンク |
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関連識別子 |
http://hdl.handle.net/10271/0002000064 |
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関連名称 |
学位論文要旨 |
| 出版タイプ |
|
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
JEADV-37-2526.pdf (1.2 MB)
