| アイテムタイプ |
共通アイテムタイプ_旧(1) |
| 公開日 |
2025-10-21 |
| タイトル |
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|
タイトル |
Associations of plasma aprepitant and its N-dealkylated metabolite with cachexia status and clinical responses in head and neck cancer patients |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題 |
aprepitant |
| キーワード |
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|
主題 |
metabolite |
| キーワード |
|
|
主題 |
pharmacokinetics |
| キーワード |
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|
主題 |
cachexia |
| キーワード |
|
|
主題 |
CINV |
| その他のタイトル |
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その他のタイトル |
頭頸部がん患者における血漿中アプレピタント及びそのN-脱アルキル化代謝物と悪液質の進行及び臨床効果との関連性 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Suzuki, Yusuke
Naito, Takafumi
Shibata, Kaito
Hosokawa, Seiji
Kawakami, Junichi
|
| 著者情報 |
鈴木, 祐介
川上, 純一
|
| 書誌情報 |
en : Cancer Chemotherapy and Pharmacology
巻 91,
号 6,
p. 481-490,
発行日 2023-06
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| 出版者 |
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出版者 |
Springer Nature |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00280-023-04537-4 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Oral aprepitant has a large interindividual variation in clinical responses in advanced cancer. This study aimed to characterize plasma aprepitant and its N-dealkylated metabolite (ND-AP) based on the cachexia status and clinical responses in head and neck cancer patients.
Methods: Fifty-three head and neck cancer patients receiving cisplatin-based chemotherapy with oral aprepitant were enrolled. Plasma concentrations of total and free aprepitant and ND-AP were determined at 24 hours after a 3-day aprepitant treatment. The clinical responses to aprepitant and degrees of cachexia status were assessed using a questionnaire and Glasgow Prognostic Score (GPS).
Results: Serum albumin level was negatively correlated with the plasma concentrations of total and free aprepitant but not ND-AP. The serum albumin level had a negative correlation with the metabolic ratio of aprepitant. The patients with GPS 1 or 2 had higher plasma concentrations of total and free aprepitant than those with GPS 0. No difference was observed in the plasma concentration of ND-AP between the GPS classifications. The plasma interleukin-6 level was higher in patients with GPS 1 or 2 than 0. The absolute plasma concentration of free ND-AP was higher in patients without the delayed nausea, and its concentration to determine the occurrence was 18.9ng/mL. The occurrence of delayed nausea had no relation with absolute plasma aprepitant.
Conclusion: Cancer patients with a lower serum albumin and progressive cachectic condition had a higher plasma aprepitant level. In contrast, plasma free ND-AP but not aprepitant was related to the antiemetic efficacy of oral aprepitant. |
| 注記 |
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|
内容記述 |
乙第606号 学位論文の出版タイプが異なる版 |
| PISSN |
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収録物識別子 |
0344-5704 |
| EISSN |
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収録物識別子 |
1432-0843 |
| NII書誌ID (NCID) |
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収録物識別子 |
AA00598397 |
| PubMed番号 (PMID) |
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関連識別子 |
37140601 |
| 出版社DOI |
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関連識別子 |
https://doi.org/10.1007/s00280-023-04537-4 |
| 要旨⇔論文へのリンク |
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関連識別子 |
http://hdl.handle.net/10271/0002000117 |
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関連名称 |
学位論文要旨 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
CCP-91-481.pdf (1.7 MB)
