| Item type |
共通アイテムタイプ / Common item types(1) |
| 公開日 |
2025-10-21 |
| タイトル |
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|
タイトル |
Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
volatile anesthesia |
| キーワード |
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|
主題 |
perioperative care |
| キーワード |
|
|
主題 |
circadian rhythm |
| その他のタイトル |
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|
その他のタイトル |
吸入麻酔薬がマウスの概日リズムに及ぼす作用：セボフルラン、デスフルラン、イソフルランの比較 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sugimura, Sho
Imai, Ryo
Katoh, Takasumi
Makino, Hiroshi
Hokamura, Kazuya
Kurita, Tadayoshi
Suzuki, Yasuhito
Aoki, Yoshitaka
Kimura, Tetsuro
Umemura, Kazuo
Nakajima, Yoshiki
|
| 著者情報 |
杉村, 翔
今井, 亮
加藤, 孝澄
牧野, 洋
外村, 和也
栗田, 忠代士
鈴木, 康仁
青木, 善孝
木村, 哲朗
梅村, 和夫
中島, 芳樹
|
| 書誌情報 |
en : Journal of Anesthesia
巻 38,
号 1,
p. 10-18,
発行日 2024-02
|
| 出版者 |
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出版者 |
Springer Nature |
| 出版者 |
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出版者 |
日本麻酔科学会 = Japanese Society of Anesthesiologists |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00540-023-03262-9 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Volatile anesthetics affect the circadian rhythm of mammals, although the effects of different types of anesthetics are unclear. Here, we anesthetized mice using several volatile anesthetics at two different times during the day. Our objective was to compare the effects of these anesthetics on circadian rhythm. Methods: Male adult C57BL/6J mice were divided into eight groups (n=8 each) based on the anesthetic (sevoflurane, desflurane, isoflurane, or no anesthesia) and anesthesia time (Zeitgeber time [ZT] 6–12 or ZT18–24). Mice were anesthetized for 6 hours using a 0.5 minimum alveolar concentration (MAC) dose under constant dark conditions. The difference between the start of the active phase before and after anesthesia was measured as a phase shift. Clock genes were measured by polymerase chain reaction in suprachiasmatic nucleus (SCN) samples removed from mouse brain after anesthesia (n=8–9 each). Results: Phase shift after anesthesia at ZT6–12 using sevoflurane (-0.49 hour) was smaller compared with desflurane (-1.1 hour) and isoflurane (-1.4 hour) (p<0.05). Clock mRNA (ZT6–12, p<0.05) and Per2 mRNA (ZT18–24, p<0.05) expression were different between the groups after anesthesia. Conclusion: 0.5 MAC sevoflurane anesthesia administered during the late inactive to early active phase has less impact on the phase shift of circadian rhythm than desflurane and isoflurane. This may be due to differences in the effects of volatile anesthetics on the expression of clock genes in the SCN, the master clock of the circadian rhythm. |
| 注記 |
|
|
内容記述 |
甲第981号 学位論文の出版タイプが異なる版 |
| PISSN |
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|
収録物識別子 |
0913-8668 |
| EISSN |
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収録物識別子 |
1438-8359 |
| NII書誌ID (NCID) |
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収録物識別子 |
AA10852931 |
| PubMed番号 (PMID) |
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関連識別子 |
37741919 |
| 医中誌論文ID (ICHUSHI) |
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関連識別子 |
2025095216 |
| 出版社DOI |
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関連識別子 |
https://doi.org/10.1007/s00540-023-03262-9 |
| 要旨⇔論文へのリンク |
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関連識別子 |
http://hdl.handle.net/10271/0002000131 |
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関連名称 |
学位論文要旨 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
J.Anesth-38-10.pdf (1.1 MB)
