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アイテム
Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer
http://hdl.handle.net/10271/0002000479
http://hdl.handle.net/10271/0002000479264d56dd-636f-4a8f-bc05-7a22d676f601
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (4.1 MB)
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| Item type | 共通アイテムタイプ / Common item types(1) | |||||||||||
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| 公開日 | 2025-08-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | Opioid receptors | |||||||||||
| キーワード | ||||||||||||
| 主題 | Oral cavity cancer | |||||||||||
| キーワード | ||||||||||||
| 主題 | Liquid biopsy | |||||||||||
| キーワード | ||||||||||||
| 主題 | Circulating tumor DNA | |||||||||||
| キーワード | ||||||||||||
| 主題 | G protein-coupled receptor | |||||||||||
| キーワード | ||||||||||||
| 主題 | Epigenetic markers | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | 口腔がんのオピオイド受容体遺伝子メチル化解析による新たな予後評価とリキッドバイオプシーの潜在的有用性について | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
石川, 竜司
× 石川, 竜司
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| 書誌情報 |
en : Current Problems in Cancer 巻 46, 号 2, p. 100834, 発行日 2022-04 |
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| 出版者 | ||||||||||||
| 出版者 | Elsevier | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright 2021 Elsevier Inc. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Opioids are a class of recreational drugs and prescription medications that bind to a group of G-protein-coupled receptors known as opioid receptors (ORs). ORs are involved in the development of many types of cancer; however, their role in head and neck squamous cell carcinoma (HNSCC) is complex and poorly understood. Here, we analyzed the methylation status of five OR genes in verification (301 HNSCC primary samples) and validation (five circulating tumor DNA [ctDNA] samples) studies using quantitative methylation-specific PCR (Q-MSP). OPRL1 and OPRM1 methylation levels were significantly higher in HNSCC tissues than in corresponding normal tissues from the same individuals (P=0.001 and P<0.001, respectively). In Kaplan-Meier estimate and multivariate Cox proportional hazard analyses, two genes (OPRL1 and OPRM1) were significantly associated with increased recurrence in the methylation group with oral cavity cancer. Furthermore, a validation study of ctDNA demonstrated that OPRL1 genes exhibited predictive performance as emerging biomarkers and were each capable of discriminating the plasma from tumor-free individuals. We characterized the relationship between OR gene methylation status and outcomes in oral cavity cancer. Our results highlight the potential utility of ctDNA methylation-based detection in the clinical management of oral cavity cancer. | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与機関名 | Hamamatsu University School of Medicine | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2023-06-16 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 乙第599号 | |||||||||||
| PISSN | ||||||||||||
| 収録物識別子 | 0147-0272 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子 | 1535-6345 | |||||||||||
| NII書誌ID (NCID) | ||||||||||||
| 収録物識別子 | AA00622006 | |||||||||||
| PubMed番号 (PMID) | ||||||||||||
| 関連識別子 | 35042636 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.currproblcancer.2021.100834 | |||||||||||
| 学位論文要旨/本文へのリンク | ||||||||||||
| 関連識別子 | http://hdl.handle.net/10271/0002000001 | |||||||||||
| 関連名称 | 学位論文要旨 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
