{"created":"2025-08-04T06:22:05.221920+00:00","id":2000479,"links":{},"metadata":{"_buckets":{"deposit":"2c3e7d7a-0024-4d57-bfb1-17941f21976b"},"_deposit":{"created_by":4,"id":"2000479","owner":"4","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2000479"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:02000479","sets":["2:15:17"]},"author_link":[],"control_number":"2000479","item_1747115756369":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"35042636","subitem_relation_type_select":"PMID"}}]},"item_1747115938917":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.currproblcancer.2021.100834","subitem_relation_type_select":"DOI"}}]},"item_1747116992798":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00622006","subitem_source_identifier_type":"NCID"}]},"item_1747119187110":{"attribute_name":"学位の区分","attribute_value_mlt":[{"subitem_description":"doctoral","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1747119200876":{"attribute_name":"学位の分野","attribute_value_mlt":[{"subitem_description":"医学系研究科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_1748498410707":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1749433886912":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1535-6345","subitem_source_identifier_type":"EISSN"}]},"item_1751527345221":{"attribute_name":"学位論文要旨/本文へのリンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"学位論文要旨"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10271/0002000001","subitem_relation_type_select":"HDL"}}]},"item_30001_access_rights4":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_30001_alternative_title1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"口腔がんのオピオイド受容体遺伝子メチル化解析による新たな予後評価とリキッドバイオプシーの潜在的有用性について","subitem_alternative_title_language":"ja"}]},"item_30001_bibliographic_information17":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"100834","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Current Problems in Cancer","bibliographic_titleLang":"en"}]}]},"item_30001_creator2":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000089376696","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000089376696"},{"affiliationNameIdentifier":"00ndx3g44","affiliationNameIdentifierScheme":"ROR","affiliationNameIdentifierURI":"https://ror.org/00ndx3g44"}],"affiliationNames":[{"affiliationName":"浜松医科大学","affiliationNameLang":"ja"},{"affiliationName":"ハママツイカダイガク","affiliationNameLang":"ja-Kana"},{"affiliationName":"Hamamatsu University School of Medicine","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"石川, 竜司","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"イシカワ, リュウジ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"},{"creatorName":"Ishikawa, Ryuji","creatorNameLang":"en","creatorNameType":"Personal"}]}]},"item_30001_date_granted20":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-06-16"}]},"item_30001_degree_grantor21":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"浜松医科大学"},{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hamamatsu University School of Medicine"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13802","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_30001_degree_name19":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_30001_description8":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Opioids are a class of recreational drugs and prescription medications that bind to a group of G-protein-coupled receptors known as opioid receptors (ORs). ORs are involved in the development of many types of cancer; however, their role in head and neck squamous cell carcinoma (HNSCC) is complex and poorly understood. Here, we analyzed the methylation status of five OR genes in verification (301 HNSCC primary samples) and validation (five circulating tumor DNA [ctDNA] samples) studies using quantitative methylation-specific PCR (Q-MSP). OPRL1 and OPRM1 methylation levels were significantly higher in HNSCC tissues than in corresponding normal tissues from the same individuals (P=0.001 and P<0.001, respectively). In Kaplan-Meier estimate and multivariate Cox proportional hazard analyses, two genes (OPRL1 and OPRM1) were significantly associated with increased recurrence in the methylation group with oral cavity cancer. Furthermore, a validation study of ctDNA demonstrated that OPRL1 genes exhibited predictive performance as emerging biomarkers and were each capable of discriminating the plasma from tumor-free individuals. We characterized the relationship between OR gene methylation status and outcomes in oral cavity cancer. Our results highlight the potential utility of ctDNA methylation-based detection in the clinical management of oral cavity cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_30001_dissertation_number18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第599号"}]},"item_30001_file22":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-08-04"}],"displaytype":"detail","filename":"DT_ron599ronbun.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"論文本文","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2000479/files/DT_ron599ronbun.pdf"},"version_id":"4d054567-7438-42c8-a2bd-e07e51f46dbc"}]},"item_30001_language10":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_30001_publisher9":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_30001_rights5":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright  2021 Elsevier Inc.","subitem_rights_language":"en"}]},"item_30001_source_identifier16":{"attribute_name":"PISSN","attribute_value_mlt":[{"subitem_source_identifier":"0147-0272","subitem_source_identifier_type":"PISSN"}]},"item_30001_subject7":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Opioid receptors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral cavity cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Liquid biopsy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Circulating tumor DNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"G protein-coupled receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epigenetic markers","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_30001_title0":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer","subitem_title_language":"en"}]},"item_30001_version_type12":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_title":"Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer","item_type_id":"40002","owner":"4","path":["17"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-08-21"},"publish_date":"2025-08-21","publish_status":"0","recid":"2000479","relation_version_is_last":true,"title":["Novel prognostic value and potential utility of opioid receptor gene methylation in liquid biopsy for oral cavity cancer"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2025-08-21T05:22:16.395193+00:00"}