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Long-term effects of diffuse idiopathic skeletal hyperostosis on physical function: A longitudinal analysis
http://hdl.handle.net/10271/0002000482
http://hdl.handle.net/10271/0002000482fd4d36e2-9b8b-4638-b5b8-4b9561024afb
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論文本文 (3.9 MB)
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| Item type | 共通アイテムタイプ / Common item types(1) | |||||||||||
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| 公開日 | 2025-08-21 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Long-term effects of diffuse idiopathic skeletal hyperostosis on physical function: A longitudinal analysis | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | Diffuse idiopathic skeletal hyperostosis | |||||||||||
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| 主題 | Case-control study | |||||||||||
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| 主題 | Bone mineral density | |||||||||||
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| 主題 | Health-related quality of life | |||||||||||
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| 主題 | Spinal-pelvic parameters | |||||||||||
| その他のタイトル | ||||||||||||
| その他のタイトル | 身体機能におけるびまん性特発性骨増殖症の長期的影響 ―縦断的研究― | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||||||
| 資源タイプ | doctoral thesis | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
Li, Shuo
× Li, Shuo
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| 著者情報 |
リ, シュオ
× リ, シュオ
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| 書誌情報 |
en : Journal of Orthopaedic Science 巻 29, 号 1, p. 109-114, 発行日 2023-12-29 |
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| 出版者 | ||||||||||||
| 出版者 | Elsevier | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 日本整形外科学会 = The Japanese Orthopaedic Association | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | Copyright 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Background: Cross-sectional studies on diffuse idiopathic skeletal hyperostosis have focused on its incidence and related factors. However, the long-term changes caused by the disease remain unclear. This longitudinal cohort study aimed to elucidate the progression of diffuse idiopathic skeletal hyperostosis and its effects on physical function, health-related quality of life, and spinal alignment. Methods: We recruited 255 older adults (87 men and 168 women; average age, 71.3 years in 2014) who attended local health checkups in 2014 and 2020. Height, body weight, body mass index, blood pressure, grip strength, functional reach, and bone mineral density were measured. The prevalence, location, number of ossified contiguous vertebrae, and spinopelvic parameters were estimated using whole-spine standing radiographs. For health-related quality of life assessment, the Oswestry disability index and EuroQuol-5D were obtained. We performed a 1:1 case-control study with age and sex-matched patients with and without diffuse idiopathic skeletal hyperostosis and analyzed progression over a 6-year period. Results: In 2014, 39 (15.3%) of 255 patients were diagnosed with diffuse idiopathic skeletal hyperostosis (24 males and 15 females), which occurred more frequently in the elderly and males. In 2020, 12 (4.3%) patients were newly diagnosed with diffuse idiopathic skeletal hyperostosis, and 28 (71.7%) of 39 patients diagnosed in 2014 showed varying degrees of progression. Compared with age- and sex-matched patients without diffuse idiopathic skeletal hyperostosis, patients with the condition had higher body mass index and lumbar bone mineral density, larger sagittal vertical axis, and greater T1-pelvic angle. Changes in physical function and spinal-pelvic parameters during the 6-year period did not differ between the groups. Conclusions: Over a 6-year period, the prevalence of diffuse idiopathic skeletal hyperostosis increased by 4.3%, and it progressed in 71.7% of patients. However, it had little effect on longitudinal physical function, health-related quality of life, and spinopelvic parameters in older adults. |
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| 学位名 | ||||||||||||
| 学位名 | 博士（医学） | |||||||||||
| 学位の区分 | ||||||||||||
| 内容記述 | doctoral | |||||||||||
| 学位の分野 | ||||||||||||
| 内容記述 | 医学系研究科 | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 浜松医科大学 | |||||||||||
| 学位授与機関名 | Hamamatsu University School of Medicine | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2023-09-22 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第954号 | |||||||||||
| PISSN | ||||||||||||
| 収録物識別子 | 0949-2658 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子 | 1436-2023 | |||||||||||
| NII書誌ID (NCID) | ||||||||||||
| 収録物識別子 | AA11052566 | |||||||||||
| PubMed番号 (PMID) | ||||||||||||
| 関連識別子 | 36669955 | |||||||||||
| 医中誌論文ID (ICHUSHI) | ||||||||||||
| 関連識別子 | 2025142348 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.jos.2022.12.014 | |||||||||||
| 学位論文要旨/本文へのリンク | ||||||||||||
| 関連識別子 | http://hdl.handle.net/10271/0002000043 | |||||||||||
| 関連名称 | 学位論文要旨 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
