{"created":"2023-06-20T15:47:29.098997+00:00","id":2025,"links":{},"metadata":{"_buckets":{"deposit":"79658708-a55d-4bdb-9e94-148a52ea7845"},"_deposit":{"created_by":2,"id":"2025","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2025"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002025","sets":["1:11"]},"author_link":["5286","5285","5284"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"129","bibliographicPageStart":"124","bibliographicVolumeNumber":"864","bibliographic_titles":[{"bibliographic_title":"Brain Research"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have examined using microdialysis the effect of intracranial self-stimulation (ICSS) on the in vivo hydroxylation rate of tyrosine and tryptophan in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC) and striatum (STR). A decarboxylase inhibitor NSD-1015 was included in the perfusate, which enabled the simultaneous measurement of 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) as an index of the in vivo hydroxylation level of tyrosine and tryptophan. When rats were exposed to 1 h of ICSS at the medial forebrain bundle (MFB), their extracellular levels of DOPA significantly increased in the mPFC, NAC and STR, but with a different magnitude and time course. The same stimulation produced a delayed increase in extracellular 5-HTP, compared to DOPA, in these brain regions. The profile of 5-HTP response demonstrated no apparent difference among the regions. These findings indicate that ICSS of the MFB can increase differentially the in vivo hydroxylation of tyrosine but similarly the in vivo hydroxylation of tryptophan in the mPFC, NAC and STR.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Science B.V"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0006-8993(00)02166-1","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2000 Elsevier Science B.V."}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00068993","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Masato"}],"nameIdentifiers":[{"nameIdentifier":"5284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Hiromu"}],"nameIdentifiers":[{"nameIdentifier":"5285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuno, Nario"}],"nameIdentifiers":[{"nameIdentifier":"5286","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"BrainRes864_1-124.pdf","filesize":[{"value":"701.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BrainRes864_1-124.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2025/files/BrainRes864_1-124.pdf"},"version_id":"3258474a-bb88-4a9b-9a7b-33e093f532f8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"3,4-Dihydroxyphenylalanine","subitem_subject_scheme":"Other"},{"subitem_subject":"5-Hydroxytryptophan","subitem_subject_scheme":"Other"},{"subitem_subject":"Intracranial self-stimulation","subitem_subject_scheme":"Other"},{"subitem_subject":"Medial prefrontal cortex","subitem_subject_scheme":"Other"},{"subitem_subject":"Nucleus accumbens","subitem_subject_scheme":"Other"},{"subitem_subject":"Striatum","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum"}]},"item_type_id":"3","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2025","relation_version_is_last":true,"title":["Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-06-20T17:23:42.055534+00:00"}