{"created":"2023-06-20T15:47:29.569081+00:00","id":2032,"links":{},"metadata":{"_buckets":{"deposit":"e4f3b80e-fba1-444f-b077-12d71d03f819"},"_deposit":{"created_by":2,"id":"2032","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2032"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002032","sets":["1:11"]},"author_link":["5313","5312","5314","5316","5315"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"505","bibliographicPageStart":"499","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"日本臨床免疫学会会誌"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】難治RAに対するLCAPの臨床的有用性を検討した．【対象および方法】対象は，1) DMARDsや生物学的製剤に治療抵抗性を示した，または2) 副作用及び合併症のため薬剤継続が困難であったRA13例（男性5例，女性8例，平均年齢60.8±11.4歳）．LCAPは週1回（平均処理量4.58±1.00 L），計5回を1クールとし，その前後でDAS28（CRP）にて病勢を評価し，また有害事象について検討した．【結果】開始前のDAS28（CRP）は5.70±1.12，1クール終了後は4.57±1.19，終了時から約4週後では4.83±1.35であった．また，一過性の貧血は見られたが，4週後には改善しており，重篤な有害事象は見られなかった．【結論】LCAPは難治性のRAに対し有効な選択肢であることが示唆された．今後どのような症例に適用すべきか更なる検討が必要である．","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床免疫学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2177/jsci.32.499","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2009 日本臨床免疫学会"},{"subitem_rights":"本文データは学協会の許諾に基づきJ-STAGEから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09114300","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13497413","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤田, 仁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木本, 理"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 大介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"下山, 久美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 法良"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JJClinImmunol32_6-499.pdf","filesize":[{"value":"722.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JJClinImmunol32_6-499.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2032/files/JJClinImmunol32_6-499.pdf"},"version_id":"a46b36c5-e58c-4a98-af6e-5954112a284a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LCAP (Leukocytapheresis)","subitem_subject_scheme":"Other"},{"subitem_subject":"DAS28 (CRP)","subitem_subject_scheme":"Other"},{"subitem_subject":"adverse events","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"難治性関節リウマチ(RA)に対する白血球除去療法(LCAP)の臨床的有用性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"難治性関節リウマチ(RA)に対する白血球除去療法(LCAP)の臨床的有用性の検討"}]},"item_type_id":"3","owner":"2","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2032","relation_version_is_last":true,"title":["難治性関節リウマチ(RA)に対する白血球除去療法(LCAP)の臨床的有用性の検討"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-06-20T17:23:33.116578+00:00"}