{"created":"2023-06-20T15:47:29.710732+00:00","id":2034,"links":{},"metadata":{"_buckets":{"deposit":"a4c04f88-a5bf-41b9-b7d9-2dd5b27bebc7"},"_deposit":{"created_by":2,"id":"2034","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"2034"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002034","sets":["1:11"]},"author_link":["5323","5331","5332","5324","5326","5333","5330","5328","5329","5325","5327"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"413","bibliographicPageStart":"408","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"日本臨床免疫学会会誌"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的:近年，関節リウマチ（rheumatoid arthritis ; RA）の診療において，抗環状シトルリン化ペプチド抗体（anti-cyclic citrullinated peptide antibody:抗CCP抗体）は感度，特異度が高く注目されている．我々は抗CCP抗体のRA診療における有用性について検討した．対象と方法:多発関節痛症例115例（女性89例，男性26例）に関して抗CCP抗体，ESR, CRP, IgM-RF, IgG-RF, RAPA, CARF, MMP-3, C1q-IC, Stage, Class, Joint score, Sharp score, KL-6, SP-D，胸部CTを検討した．結果:抗CCP抗体は，特異度（93.5%）に優れていた．またRA群（45例）において，抗CCP抗体陽性群のSharp score (10.9±22.4）は，抗CCP抗体陰性群（1.7±1.8）と比べて有意に高値であり（P<0.05），関節破壊の指標となる可能性が示唆された．間質性肺炎併発例における抗CCP抗体値（84.5±36.4 U/mL）は間質性肺炎非合併例（52.6±44.7 U/mL）に比べ，有意に高値であった（P<0.05）．総括:抗CCP抗体は特異度が高く，骨関節破壊のマーカーとなる可能性がある．特定の臓器障害や病勢との関連性に関しては，今後さらなる検討が必要であると考えられる．","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床免疫学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2177/jsci.30.408","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2007 日本臨床免疫学会"},{"subitem_rights":"本文データは学協会の許諾に基づきJ-STAGEから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09114300","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13497413","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下山, 久美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 法良"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂井, 知之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤木, 俊興"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河南, 崇典"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"唐澤, 博美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"正木, 康史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 真生"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福島, 俊洋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"廣瀬, 優子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"梅原, 久範"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JJClinImmunol30_5-408.pdf","filesize":[{"value":"424.2 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