{"created":"2023-06-20T15:47:49.022939+00:00","id":2350,"links":{},"metadata":{"_buckets":{"deposit":"d9748fd5-f57a-4801-8480-716458ecdfeb"},"_deposit":{"created_by":4,"id":"2350","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2350"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002350","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-02-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"187","bibliographicPageStart":"181","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Japanese circulation journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to clarify the pathological involvement of the sympathetic nervous system in the development of cardiomyopathy, a receptor-binding study was carried out on cardiomyopathic Syrian hamsters of strain BIO 14.6 (BIO) at 21 days (prenecrotic stage); 35-42 days (onset of cardiomyopathy); and 70-84 days of life (early cardiac hypertrophy). The newly developed α_1-blocker (bunazosin hydrochloride) was initially administered at doses of 100 μg/kg or 10 mg/kg BIO hamsters at 21 days of life and continued for 70 days. At the onset of cardiomyopathy and early cardiac hypertrophy, there was an increase in the number of α_1-receptors in the BIO hamsters compared to controls, but there were no significant changes at the prenecrotic stage. On histopathological examination, 10 mg/kg bunazosin had a singnificant beneficial effect on cardiomyopathy [area of necrosis 1.38% in untreated vs 0.33% in treated animals; area of calcification 2.70% (untreated) vs 0.60% (treated); area of all myocardial injuries 6.97% (untreated) vs 3.19% (treated)]. However, 100 μg/kg bunazosin had no effect. It was concluded that the increase in the number of α_1-receptors may not be involved in the pathogenesis of cardiomyopathy but that α_1-receptors could be implicated in the later progression of the condition.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/jcj.52.181","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 日本循環器学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00471828","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikegaya, Takayoshi"}]},{"creatorNames":[{"creatorName":"Nishiyama, Terumasa"}]},{"creatorNames":[{"creatorName":"Kobayashi, Akira"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"CircJ52_2-181.pdf","filesize":[{"value":"968.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CircJ52_2-181.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2350/files/CircJ52_2-181.pdf"},"version_id":"f8295c9a-2869-4c3d-9ac9-32bbe9727f7f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α_1 -adrenergic receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiomyopathic syrian hamster","subitem_subject_scheme":"Other"},{"subitem_subject":"Bunazosin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"R０LE OF α1-ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"R０LE OF α1-ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2350","relation_version_is_last":true,"title":["R０LE OF α1-ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T04:53:48.720292+00:00"}